1276029-08-3Relevant academic research and scientific papers
Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase1
Spinks, Daniel,Ong, Han B.,Mpamhanga, Chidochangu P.,Shanks, Emma J.,Robinson, David A.,Collie, Iain T.,Read, Kevin D.,Frearson, Julie A.,Wyatt, Paul G.,Brenk, Ruth,Fairlamb, Alan H.,Gilbert, Ian H.
, p. 302 - 308 (2011)
Genetic studies indicate that the enzyme pteridine reductase1 (PTR1) is essential for the survival of the protozoan parasite Trypanosoma brucei. Herein, we describe the development and optimisation of a novel series of PTR1 inhibitors, based on benzo[d]im
