1276056-83-7

Basic information

• Product Name: (4-broMo-1-Methyl-1H-pyrazol-5-yl)Methanol
• Synonyms: (4-broMo-1-Methyl-1H-pyrazol-5-yl)Methanol;(4-Bromo-2-methyl-pyrazol-3-yl)methanol
• CAS NO: 1276056-83-7
• Molecular Formula: C₅H₇BrN₂O
• Molecular Weight: 191
• Mol File: 1276056-83-7.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-broMo-1-Methyl-1H-pyrazol-5-yl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (4-broMo-1-Methyl-1H-pyrazol-5-yl)Methanol(1276056-83-7)
• EPA Substance Registry System: (4-broMo-1-Methyl-1H-pyrazol-5-yl)Methanol(1276056-83-7)

Safety Data

• Hazardous Substances Data: 1276056-83-7(Hazardous Substances Data)

Usage

General Description

(4-bromo-1-methyl-1H-pyrazol-5-yl)methanol is a chemical compound with the molecular formula C6H7BrN2O. It is a white to off-white solid that is commonly used in medicinal chemistry as a building block for the synthesis of various pharmaceuticals and agrochemicals. (4-broMo-1-Methyl-1H-pyrazol-5-yl)Methanol is also known for its use in the development of novel drug candidates for the treatment of various diseases. It can be synthesized through various chemical reactions and has been the subject of research for its potential therapeutic applications. Overall, (4-bromo-1-methyl-1H-pyrazol-5-yl)methanol is a valuable chemical compound with diverse uses in the pharmaceutical and agrochemical industries.

Upstream product

• 514816-42-3 4-bromo-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 27258-33-9 1-methyl-1H-pyrazole-5-carbaldehyde 
• 1269291-90-8 5-(dimethoxymethyl)-1-methyl-1H-pyrazole 
• 473528-88-0 4-bromo-1-methyl-1H-pyrazole-5-carboxaldehyde 
• 84547-84-2 4-bromo-2-methyl-2H-pyrazole-3-carboxylic acid 

Downstream Products

• 1350323-54-4 (4-{3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-1-methyl-1H-pyrazol-5-yl)methanol 

Relevant articles and documents

MACROCYCLES AND THEIR USE

The present disclosure relates to macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as cancer.

Lysophosphatidic acid receptor antagonists and preparation method thereof

The invention belongs to the technical field of medicinal chemistry, and particularly relates to lysophosphatidic acid receptor antagonists and a preparation method thereof. The applicant surprisinglyfinds that compounds provided by the invention have high LPAR1 antagonistic activity and selectivity, low toxicity, good metabolic stability and good drug development prospect, and can be used for preventing or treating diseases or symptoms related to LPAR1. The applicant also accidentally finds that the IC50 value of part of the compounds can be as low as 300 nM or below and even 50 nM or below.Moreover, the compounds disclosed by the invention have better safety, and the CC50 range of the compounds can reach 200 [mu]M or above. In addition, the compounds of the present invention have goodmetabolic stability in humans, rats, and mice, such excellent inhibitory activity being very desirable for their use as LPAR1 inhibitors in the above diseases or disorders. In addition, the preparation method of the compounds is simple, mild in reaction condition, high in product yield and suitable for industrial production.

SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF

The present disclosure relates to novel compounds including formula (X) and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.