1276111-29-5Relevant academic research and scientific papers
Enantioselective α-arylation of aldehydes via the productive merger of iodonium salts and organocatalysis
Allen, Anna E.,MacMillan, David W. C.
supporting information; experimental part, p. 4260 - 4263 (2011/06/21)
The enantioselective α-arylation of aldehydes has been accomplished using diaryliodonium salts and a combination of copper and organic catalysts. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-formyl benzylic stereocenters, a valuable synthon for the production of medicinal agents. As one example, this new asymmetric protocol has been applied to the rapid synthesis of (S)-ketoprofen, a commercially successful oral and topical analgesic.
Enantioselective α-arylation of N-acyloxazolidinones with copper(II)-bisoxazoline catalysts and diaryliodonium salts
Bigot, Aurelien,Williamson, Alice E.,Gaunt, Matthew J.
supporting information; experimental part, p. 13778 - 13781 (2011/10/09)
A new strategy for the catalytic enantioselective α-arylation of N-acyloxazolidinones with chiral copper(II)-bisoxazoline complexes and diaryliodonium salts is described. The mild catalytic conditions are operationally simple, produce valuable synthetic building blocks in excellent yields and enantioselectivities, and can be applied to the synthesis of important nonsteroidal anti-inflammatory agents and their analogues.
