1276113-39-3

Upstream product

• 91430-70-5 ethyl 3-amino-4-(2-hydroxyethylamino)benzoate 
• 104-87-0 4-methyl-benzaldehyde 
• 91214-94-7 ethyl 4-(2-hydroxyethylamino)-3-nitrobenzoate 
• 367-80-6 ethyl 4-fluoro-3-nitrobenzoate 
• 453-71-4 3-nitro-4-fluorobenzoic acid 
• 41468-10-4 α-hydroxy-α-toluenesulfonate 

Downstream Products

• 1403576-35-1 C₅₃H₅₄N₂O₈ 
• 1403576-39-5 C₂₅H₃₀N₂O₈ 

Relevant academic research and scientific papers

Total synthesis of diversified 1,2-disubstituted benzimidazoles with green approach at room temperature

A green and facile method to synthesize diversified 1,2-disubstituted benzimidazoles has been developed. The total synthesis was performed at room temperature utilizing water and ethanol as solvents. As aqueous media and ethanol have low toxicity and are

Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities

A total of 15 novel benzimidazole derivatives were designed, synthesized and evaluated for their SIRT1 and SIRT2 inhibitory activity. All compounds showed better inhibition on SIRT2 as compared to SIRT1. Among these, compound 5j displayed the best inhibitory activity for SIRT1 (IC50 = 58.43 μM) as well as for SIRT2 (IC50 = 45.12 μM). Cell cytotoxicity assays also showed that compound 5j possesses good antitumor activity against two different cancer cell lines derived from breast cancer (MCF-7 and MDA-MB-468). A simple structure-activity-relationship (SAR) study of the newly synthesized benzimidazole derivatives was also discussed.

Straightforward synthesis of novel 1-(2'-α-O-D-glucopyranosyl ethyl) 2-arylbenzimidazoles

A series of novel 1-(2'-α-O-D-glucopyranosyl ethyl) 2-arylbenzimidazoles has been prepared via one-pot glycosylation of ethyl-1-(2'-hydroxyethyl)-2-arylbenzimidazole- 5-carboxylate derivatives. Synthesis of the 2-arylbenzimidazole aglycones from 4-fluoro-3- nitrobenzoic acid was accomplished in four high-yielding steps. The reduction and cyclocondensation steps for the aglycone synthesis proceeded efficiently under microwave irradiation to afford the appropriate benzimidazoles in excellent yields within 2-3 min. Glycosylation of the hydroxyethyl aglycones with the perbenzylated 1-hydroxyglucopyranose, pretreated with the Appel-Lee reagent, followed by catalytic hydrogenolysis delivered the desired 1-(2'-α-O-D- glucopyranosyl ethyl) 2-arylbenzimidazoles in a simple and straightforward manner.