1276113-64-4Relevant academic research and scientific papers
Unified Total Synthesis of Hetiamacins A–D
Tsukaguchi, Shogo,Enomoto, Masaru,Towada, Ryo,Ogura, Yusuke,Kuwahara, Shigefumi
, p. 6110 - 6116 (2019)
A concise enantioselective total synthesis of hetiamacin A has been accomplished from a known l-aspartic acid derivative by an eight-step sequence that features ammonolytic opening of the γ-lactone moiety of amicoumacin C followed by 1,3-oxazinane ring formation in one pot. Hetiamacins B–D with putatively assigned stereochemistries have also been synthesized from amicoumacin C, each in three steps involving tetrahydro-4(1H)-pyrimidinone ring formation. The excellent NMR spectroscopic agreement of the synthetic materials with the corresponding natural products, coupled with biosynthetic considerations, has enabled the full stereochemical assignments of hetiamacins B–D.
INHIBITING UBIQUITIN SPECIFIC PEPTIDASE 30
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Paragraph 00192; 00216, (2019/04/30)
The present disclosure relates to chemical entities useful as inhibitors of Ubiquitin Specific Peptidase 30 (USP30), pharmaceutical compositions comprising the chemical entities, and methods of using the chemical entities. The chemical entities as disclosed herein can be useful in the treatment of a disease, disorder, or condition involving mitochondrial dysfunction, including neurodegenerative diseases, motor neuron diseases, metabolic disorders, and cancers, among other ailments.
