127633-49-2

Basic information

• Product Name: (3RS,5S)-5-<2-(4-Bromophenyl)ethyl>-2-oxo-3-piperidinecarboxylic acid ethyl ester
• CAS NO: 127633-49-2
• Molecular Weight: 354.244
• Mol File: 127633-49-2.mol

Chemical Properties

• CAS DataBase Reference: (3RS,5S)-5-<2-(4-Bromophenyl)ethyl>-2-oxo-3-piperidinecarboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3RS,5S)-5-<2-(4-Bromophenyl)ethyl>-2-oxo-3-piperidinecarboxylic acid ethyl ester(127633-49-2)
• EPA Substance Registry System: (3RS,5S)-5-<2-(4-Bromophenyl)ethyl>-2-oxo-3-piperidinecarboxylic acid ethyl ester(127633-49-2)

Safety Data

• Hazardous Substances Data: 127633-49-2(Hazardous Substances Data)

Upstream product

• 127633-47-0 (R)-(+)-β-(Azidomethyl)-4-bromobenzenebutanol 
• 127633-44-7 (R)-(+)-2-<2-(4-Bromophenyl)ethyl>-1,3-propanediol monoacetate 
• 127633-43-6 2-<2-(4-Bromophenyl)ethyl>-1,3-propanediol 
• 84913-19-9 4-methylbenzene sulfonic acid 2-(4-bromophenyl)ethyl ester 
• 4654-39-1 4-bromophenethanol 
• 127633-57-2 (S)-<2-(Azidomethyl)-4-(4-bromophenyl)butyl>propanedioic acid diethyl ester 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 132554-00-8 (S)-(+)-2-<2-(4-Bromophenyl)ethyl>-1,3-propanediol acetate methanesulfonate 
• 127633-42-5 2-<2-(4-Bromophenyl)ethyl>propanedioic acid diethyl ester 

Downstream Products

• 127633-50-5 (S)-2-Amino-6-<2-(4-bromophenyl)ethyl>-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-4(3H)-one 
• 110672-49-6 (S)-2-{4-[2-((R)-2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid diethyl ester 
• 110672-50-9 (S)-2-{4-[2-((S)-2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid diethyl ester 
• 95693-76-8 lometrexol 
• 106400-18-4 (6S)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid 
• 136210-13-4 (S)-4-<2-(2-Amino-1,4,5,6,7,8-hexahydro-4-oxopyrido<2,3-d>pyrimidin-6-yl)ethyl>benzonic acid 
• 127633-59-4 (S)-4-<2-(2-Amino-1,4,5,6,7,8-hexahydro-4-oxopyrido<2,3-d>pyrimidin-6-yl)ethyl>benzonitrile 

Relevant articles and documents

Asymmetric synthesis of lometrexol ((6R)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid)

An enantioselective synthesis of lometrexol (1) which utilizes (5R)-2-piperidone 18 as a key intermediate is described. Lipase-catalyzed enantioselective esterification of 1,3-propanediol derivative 5 provided (R)-(+)-6, the absolute configuration of whic

Enantioselective synthesis of antifolates

A process and intermediates for the enantioselective synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid are disclosed.

Asymmetric synthesis and absolute configuration of 5,10-dideaza-5,6,7,8-tetrahydropteroic acid and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF)

Lipase-catalyzed enantioselective esterification of 2-substituted 1,3-diols has been utilized in the asymmetry synthesis and consequent configurational assignments of the title compounds.