127641-47-8Relevant academic research and scientific papers
Rational design of CH/π interaction sites in a basic resolving agent
Kobayashi, Yuka,Kurasawa, Toshie,Kinbara, Kazushi,Saigo, Kazuhiko
, p. 7436 - 7441 (2007/10/03)
A novel synthetic basic resolving agent, cis-1-aminobenz[f]indan-2-ol (ABI), was rationally designed by introducing effective CH/π interaction sites to cis-1-aminoindan-2-ol (AI), whose chiral recognition ability has been reported from our laboratory. ABI was applicable to a wide variety of racemic arylalkanoic acids and showed moderate to excellent chiral recognition ability, which was obviously higher than that of AI. The fundamental and important role of CH/π interactions, such as tunable CH(sp2)/π and CH(sp 3)/π interactions, in the chiral recognition by ABI was revealed by X-ray crystallographic study.
Enantioselectivity of the transfer of hydrogen atoms to acyclic prochiral carbon-centred radicals using chiral tin hydrides
Schwarzkopf, Kay,Blumenstein, Michael,Hayen, Ahlke,Metzger, Jürgen O.
, p. 177 - 181 (2007/10/03)
Racemic α-bromo esters 2 have been reduced via prochiral radicals 5 with low to moderate enantioselectivities using chiral tin hydrides 1 with a stereogenic tin atom containing chiral 2-[(1-dimethylaminoalkyl)phenyl] ligands. The tin hydrides 1 were mixtures of diastereomers. It could be shown that the minor diastereomer of tin hydrides 1a and 1b reacts with good enantioselectivity whereas the major diastereomer reacts almost unselectively. The observed enantioselectivities are also strongly influenced by steric effects of the substituents attached to the radical centre.
ENZYMATIC RESOLUTION OF METHYL 2-ALKYL-2-ARYLACETATES
Ahmar, M.,Girard, C.,Bloch, R.
, p. 7053 - 7056 (2007/10/02)
Horse liver esterase, used as its inexpensive commercial acetone powder, catalyzes the selective hydrolysis of methy 2-alkyl-2-arylacetates to afford R(-)-2-alkyl-2-arylacetic acids and S(+)-methyl 2-alkyl-2-arylacetates.
