127642-61-9Relevant articles and documents
Synthesis
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Page/Page column 9-10, (2010/02/11)
The present invention provides an improved process for the production of [(±)-endo]-4-amino-5-chloro-2-methoxy-N-(1-azabicyclo[3.3.1]non-4-yl)benzamide hydrochloride, compositions thereof, and intermediates thereto.
Substituted Benzamides with Conformationally Restricted Side Chains. 5. Azabicyclo Derivatives as 5-HT4 Receptor Agonists and Gastric Motility Stimulants
King, Frank D.,Hadley, Michael S.,Joiner, Karen T.,Martin, Roger T.,Sanger, Gareth J.,et al.
, p. 683 - 689 (2007/10/02)
The syntheses of benzamides containing azabicyclo side chains and their 5-HT4 receptor agonist and 5-HT3 receptor antagonist properties are described.These compounds were designed to mimic higher energy conformations of quinol