127652-60-2

Upstream product

• 106887-61-0 5-chloro-1,3-dimethyl-5,7-dihydro-3H-purine-2,6,8-trione 
• 200573-67-7 (1R,2S,5R)-2-[2'-hydroxy-10-methylethyl]-5-methylcyclohexan-1-ol 
• 944-73-0 1,3-dimethyluric acid 
• 2216-51-5 (-)-menthol 

Downstream Products

• 127652-62-4 1-(-)-menthoxy-2,4-dimethyl-3,7-dioxo-2,4,6,8-tetrazabicyclo<3.3.0>octane 
• 127708-76-3 1-(-)-menthoxy-2,4-dimethyl-3,7-dioxo-2,4,6,8-tetrazabicyclo<3.3.0>octane 

Relevant academic research and scientific papers

SYNTHESIS OF THE OPTICALLY ACTIVE 1,3-DIMETHYLALLANTOINS VIA (-)-MENTHYL ESTERS OF THEIR BICYCLIC TAUTOMERS

Availability of both diastereomers of 1-(-)-menthoxy-2,4-dimethyl-3,7-dioxo-2,4,6,8-tetraazabicyclooctane (5) through decarboxylative rearrangement of 5-(-)-menthoxy-1,3-dimethyl isouric acid (1) allowed the access to both enantiomers of 1,3-dimethylallantoin (6); circular dichroism spectra of the related homologues (-)-6a and (-)-allantoin proved their corresponding R-configurations.

Studies on Covalent Adducts of Dehydrouric Acid

The structure of 5-chloro and 5-alkoxy-5,7-dihydro-3H-purine-2,4,6-triones (6 and 7-9) has been corroborated by their spectral properties and X-ray crystallography.The stereochemical model (R)-10 of the key uricolytic intermediate was prepared using menth