127654-70-0

Usage

Uses

Used in Pharmaceutical Industry:
1-Chloro-3-fluoro-2-iodobenzene is used as an intermediate in the synthesis of pharmaceuticals for its unique halogenated structure, which can be further modified to create various medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical industry, 1-Chloro-3-fluoro-2-iodobenzene is utilized as an intermediate in the production of agrochemicals, contributing to the development of new pesticides and other agricultural chemicals.
Used in Organic Synthesis:
1-Chloro-3-fluoro-2-iodobenzene is employed in organic synthesis as a building block for the creation of complex organic molecules, taking advantage of its reactive halogenated benzene structure.
Used in Material Science:
In the field of material science, 1-Chloro-3-fluoro-2-iodobenzene is used as a component in the development of new materials, leveraging its unique chemical properties to enhance material performance.

Upstream product

• 625-98-9 3-chlorofluorobenzene 
• 133117-45-0 1-chloro-2-trimethylsilyl-3-fluorobenzene 

Downstream Products

• 2225909-61-3 8-bromo-1-chlorodibenzo[b,d]furan 
• 1443684-71-6 [(2-chloro-6-fluorophenyl)ethynyl](trimethyl)silane 
• 1612288-68-2 2-(2-chloro-6-fluorophenyl)-5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1416266-74-4 1-chloro-2-ethynyl-3-fluoro-benzene 
• 1612288-01-3 6-chloro-4-[(2-chloro-6-fluorophenyl)ethynyl]pyridin-3-amine 
• 1612287-97-4 5-bromo-3-[(2-chloro-6-fluorophenyl)ethynyl]pyridin-2-amine 
• 1612287-92-9 4-(5-amino-6-((2-chloro-6-fluorophenyl)ethynyl)pyrazin-2-yl)-N,3-dimethylbenzenesulfonamide 
• 1612287-89-4 4-(5-amino-6-((2-chloro-6-fluorophenyl)ethynyl)pyrazin-2-yl)-3-methylbenzenesulfonamide 
• 1612287-83-8 3-((2-chloro-6-fluorophenyl)ethynyl)-5-(2-methyl-4-(morpholinosulfonyl)phenyl)pyrazin-2-amine 
• 1612287-75-8 N-(3-((2-chloro-6-fluorophenyl)ethynyl)-5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-2-yl)-2,2,2-trifluoroacetamide 
• 1612287-74-7 3-((2-chloro-6-fluorophenyl)ethynyl)-5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-2-amine 
• 1612287-55-4 2-((2-chloro-6-fluorophenyl)ethynyl)-6-(5-methyl-3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)pyridin-3-amine 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND

Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

Photocyclodehydrofluorination

Mallory-type photocyclization involves a series of photoreactions of stilbenes, o-terphenyls and related derivatives, which undergo intramolecular cyclization via dihydrophenanthrene intermediates. In typical Mallory photocyclizations, oxidants are usually needed to produce the final phenanthrene-containing product. In the research described here, appropriately fluorinated stilbenes and o-terphenyls undergo ring closure and HF is eliminated. This photocyclodehydrofluorination (PCDHF) reaction is very useful to produce a wide range of selectively fluorinated polynuclear aromatic hydrocarbons that possess a phenanthrene (or heterocyclic analogue of phenanthrene) substructure. These fluorinated products are of great interest in various aspects of the materials science.

AZAINDOLYLPHENYL SULFONAMIDES AS SERINE/THREONINE KINASE INHIBITORS

The present invention encompasses compounds of general formula (I) wherein the groups R2 to R6, A, X, Y and m are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.

NEW AZAINDOLYLPHENYL SULFONAMIDES AS SERINE/THREONINE KINASE INHIBITORS

The present invention encompasses compounds of general formula (I) wherein the groups R2 to R6, A, X, Y and m are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.

Formation of 3-halobenzyne: Solvent effects and cycloaddition adducts

Noncoordinating solvents permit the halogen-metal exchange-induced formation of benzyne (aryne) from di- and trihalobenzene precursors in the presence of cyclopentadiene to give 1,4-dihydro-1,4-methano-naphthalenes. Studies with mixed halide precursors and nonacidic Diels-Alder diene traps reveal that ethereal and hydrocarbon solvents influence the halide leaving group facility, resulting in a reversal of 3-halobenzyne regioselectivity.