127654-70-0

Basic information

• Product Name: 1-Chloro-3-fluoro-2-iodobenzene
• Synonyms: 1-Chloro-3-fluoro-2-iodobenzene
• CAS NO: 127654-70-0
• Molecular Formula: C₆H₃ClFI
• Molecular Weight: 256
• Mol File: 127654-70-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 226.3±20.0 °C(Predicted)
• Appearance: /
• Density: 2.008±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 1-Chloro-3-fluoro-2-iodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-3-fluoro-2-iodobenzene(127654-70-0)
• EPA Substance Registry System: 1-Chloro-3-fluoro-2-iodobenzene(127654-70-0)

Safety Data

• Hazardous Substances Data: 127654-70-0(Hazardous Substances Data)

Usage

General Description

1-Chloro-3-fluoro-2-iodobenzene is a chemical compound with the molecular formula C6H3ClFI. It is a halogenated benzene derivative and has a molar mass of 240.44 g/mol. 1-Chloro-3-fluoro-2-iodobenzene is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also employed in organic synthesis and as a building block in the development of new materials. 1-Chloro-3-fluoro-2-iodobenzene is a highly reactive compound and should be handled with care in a controlled laboratory environment.

Upstream product

• 133117-45-0 1-chloro-2-trimethylsilyl-3-fluorobenzene 
• 625-98-9 3-chlorofluorobenzene 

Downstream Products

• 2225909-61-3 8-bromo-1-chlorodibenzo[b,d]furan 
• 1443684-71-6 [(2-chloro-6-fluorophenyl)ethynyl](trimethyl)silane 
• 1612288-68-2 2-(2-chloro-6-fluorophenyl)-5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine 
• 1416266-74-4 1-chloro-2-ethynyl-3-fluoro-benzene 
• 1612288-01-3 6-chloro-4-[(2-chloro-6-fluorophenyl)ethynyl]pyridin-3-amine 
• 1612287-97-4 5-bromo-3-[(2-chloro-6-fluorophenyl)ethynyl]pyridin-2-amine 
• 1612287-92-9 4-(5-amino-6-((2-chloro-6-fluorophenyl)ethynyl)pyrazin-2-yl)-N,3-dimethylbenzenesulfonamide 
• 1612287-89-4 4-(5-amino-6-((2-chloro-6-fluorophenyl)ethynyl)pyrazin-2-yl)-3-methylbenzenesulfonamide 
• 1612287-83-8 3-((2-chloro-6-fluorophenyl)ethynyl)-5-(2-methyl-4-(morpholinosulfonyl)phenyl)pyrazin-2-amine 
• 1612287-75-8 N-(3-((2-chloro-6-fluorophenyl)ethynyl)-5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-2-yl)-2,2,2-trifluoroacetamide 
• 1612287-74-7 3-((2-chloro-6-fluorophenyl)ethynyl)-5-(5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)pyridin-2-amine 
• 1612287-55-4 2-((2-chloro-6-fluorophenyl)ethynyl)-6-(5-methyl-3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)pyridin-3-amine 
• 1612287-37-2 6-bromo-2-[(2-chloro-6-fluorophenyl)ethynyl]pyridin-3-amine 

Relevant articles and documents

HETEROCYCLIC COMPOUND

Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.

AZAINDOLYLPHENYL SULFONAMIDES AS SERINE/THREONINE KINASE INHIBITORS

The present invention encompasses compounds of general formula (I) wherein the groups R2 to R6, A, X, Y and m are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.

Formation of 3-halobenzyne: Solvent effects and cycloaddition adducts

Noncoordinating solvents permit the halogen-metal exchange-induced formation of benzyne (aryne) from di- and trihalobenzene precursors in the presence of cyclopentadiene to give 1,4-dihydro-1,4-methano-naphthalenes. Studies with mixed halide precursors and nonacidic Diels-Alder diene traps reveal that ethereal and hydrocarbon solvents influence the halide leaving group facility, resulting in a reversal of 3-halobenzyne regioselectivity.