1276543-52-2

Upstream product

• 1276543-48-6 4,11-N,N'-bis(carbo-tert-butoxymethyl)-16-(4-nitrobenzyl)-1,4,8,11-tetraazabicyclo[6.6.3]heptadecane 
• 852921-64-3 1,8-N,N′-bis(carbo-tert-butoxymethyl)-1,4,8,11-tetraazacyclotetradecane 
• 463-71-8 thiophosgene 
• 1276543-55-5 4,11-bis-(benzyloxycarbonylmethyl)-16-(4-nitrobenzyl)-1,4,8,11-tetraazabicyclo[ 6.6.3]heptadecane 
• 134439-25-1 2-[(4-nitrophenyl)methyl]propan-1,3-diol bis(4-methylbenzenesulfonate) 
• 1264659-72-4 1,8-bis-(benzyloxycarbonylmethyl)-1,4,8,11-tetraazacyclotetradecane 
• 75920-10-4 1,4,8,11-tetraazatricyclo[9.3.1.14,8]hexadecane 
• 73344-98-6 2-[(4-nitrophenyl)methyl]propan-1,3-diol 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 1276543-50-0 4,11-bis-(carboxymethyl)-16-(4-aminobenzyl)-1,4,8,11-tetraazabicyclo[6.6.3]heptadecane 
• 7598-70-1 diethyl 2-(4-nitrobenzyl)malonate 

Downstream Products

• 1278402-25-7 C₅₂H₇₈N₁₄O₁₂S 

Relevant academic research and scientific papers

Propylene cross-bridged macrocyclic bifunctional chelator: A new design for facile bioconjugation and robust 64cu complex stability

The first macrocyclic bifunctional chelator incorporating propylene cross-bridge was efficiently synthesized from cyclam in seven steps. After the introduction of an extra functional group for facile conjugation onto the propylene cross-bridge, the two carboxylic acid pendants could contribute to strong coordination of Cu(II) ions, leading to a robust Cu complex. The cyclic RGD peptide conjugate of PCB-TE2A-NCS was prepared and successfully radiolabeled with 64Cu ion. The radiolabeled peptide conjugate was evaluated in vivo through a biodistribution study and animal PET imaging to demonstrate high tumor uptake with low background.

NOVEL TETRA-AZA MACROCYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF

Provided are a cross-bridged tetraaza macrocyclic compound of a novel structure that can be used, for example, as a contrast agent for diagnostic imaging or a radiopharmaceutical and a method for preparing the same. The disclosed tetraaza macrocyclic comp

NOVEL TETRAAZA MACROCYCLIC COMPOUND, PREPARATION METHOD THEREOF AND USE THEREOF

Provided are a cross-bridged tetraaza macrocyclic compound of a novel structure that can be used, for example, as a contrast agent for diagnostic imaging or a radiopharmaceutical and a method for preparing the same. The disclosed tetraaza macrocyclic compound is able to form a stable metal complex at a lower temperature and allows easy conjugation with a bioactive substance or a chemically active substance, when compared to the existing cross-bridged tetraaza macrocyclic compounds.