1276682-92-8Relevant articles and documents
Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs
Martini, Elisabetta,Di Cesare Mannelli, Lorenzo,Bartolucci, Gianluca,Bertucci, Carlo,Dei, Silvia,Ghelardini, Carla,Guandalini, Luca,Manetti, Dina,Scapecchi, Serena,Teodori, Elisabetta,Romanelli, Maria Novella
supporting information; experimental part, p. 2512 - 2516 (2011/06/24)
A series of cis and trans 3,7-diazabicyclo[4.3.0]nonan-8-ones has been synthesized and tested for their ability to revert scopolamine-induced amnesia in the mouse passive-avoidance test. The racemates of the most potent compounds 4 and 7 were separated and tested, but no enantioselectivity was found for the nootropic activity. Compounds 4 and 7 and their enantiomers displayed interesting antihyperalgesic activity in two models of neuropathic pain (streptozotocin-induced and oxalilplatin-induced neuropathy) in comparison with pregabalin.