127676-18-0

Basic information

• Product Name: 2-(5-ethyl-2-pyridyl)propane-1,3-diol
• Synonyms: 1,3-propanediol, 2-(5-ethyl-2-pyridinyl)-; 2-(5-Ethylpyridin-2-yl)propane-1,3-diol
• CAS NO: 127676-18-0
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.23
• EINECS: 603-211-1
• Mol File: 127676-18-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 360°C at 760 mmHg
• Flash Point: 171.5°C
• Density: 1.128g/cm³
• Vapor Pressure: 8.26E-06mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 2-(5-ethyl-2-pyridyl)propane-1,3-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-ethyl-2-pyridyl)propane-1,3-diol(127676-18-0)
• EPA Substance Registry System: 2-(5-ethyl-2-pyridyl)propane-1,3-diol(127676-18-0)

Safety Data

• Hazardous Substances Data: 127676-18-0(Hazardous Substances Data)

Usage

Uses

Desbenzylthiazolidinedione-2-propanediol Pioglitazone is an impurity of Pioglitazone (P471000), a compound used as an antidiabetic.

Upstream product

• 104-90-5 5-ethyl-2-methyl-pyridine 
• 50-00-0 formaldehyd 

Downstream Products

• 101931-10-6 4-[2-(5-Ethyl-pyridin-2-yl)-3-hydroxypropoxy]nitrobenzene 

Relevant articles and documents

Development of an improved and scalable process for 2-(5-ethylpyridin-2-yl) ethan-1-ol: Solvent-free reaction and recycling of the starting material 5-ethyl-2-picoline

The main objective of this exercise was to develop a more efficient process for 2-(5-ethylpyridin-2-yl)ethan-1-ol (1), which is the key intermediate in the synthesis of pioglitazone hydrochloride. This process not only features the yield improvement of (1) by optimizing reaction variables in solvent-free conditions but also highlights improving the mass efficiency of 5-ethyl-2-picoline (2), thereby reducing the effluent load per kilogram of the intermediate.