127678-01-7

Basic information

• Product Name: C₁₃H₂₃O₅PSi₂
• CAS NO: 127678-01-7
• Molecular Weight: 346.467
• Mol File: 127678-01-7.mol

Chemical Properties

• CAS DataBase Reference: C₁₃H₂₃O₅PSi₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₂₃O₅PSi₂(127678-01-7)
• EPA Substance Registry System: C₁₃H₂₃O₅PSi₂(127678-01-7)

Safety Data

• Hazardous Substances Data: 127678-01-7(Hazardous Substances Data)

Upstream product

• 1795-31-9 tris(trimethylsilyl) phosphite 
• 1885-14-9 phenyl chloroformate 

Downstream Products

• 157977-99-6 C₁₃H₁₅O₉P 
• 127678-02-8 C₁₉H₂₇O₉P 

Relevant articles and documents

Synthesis of acyloxyalkyl acylphosphonates as potential prodrugs of the antiviral, trisodium phosphonoformate (foscarnet sodium)

Bis(trimethylsilyl) acylphosphonates via their silver salts couple with iodoalkyl esters to provided an efficient synthesis of the corresponding acyloxyalkyl esters as potential prodrugs of the antiviral agent, trisodium phophonoformate. These compounds were tested as inhibitors of HIV-1 in chronically infected H9 cells.

Synthesis, hydrolytic behavior, and anti-HIV activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium)

The synthesis and anti-HIV activity of selected (acyloxy)-alkyl esters of trisodium phosphonoformate (foscarnet sodium) are described. The conversion of bis(trimethylsilyl) (alkoxycarbonyl)phosphonates 11a-d to the corresponding disilver salts 12a-d and their subsequent reaction with iodoalkyl acrylates 4a-c gave the desired bis(acyloxyalkyl) phosphonates 6- 9(a-c). Of the analogs tested, only the dichlorophenyl analog 9a showed a dose-dependent inhibition of HIV activity in H9 cells. Using 31P-NMR, bioreversibility has been investigated in an attempt to rationalize these results.