127680-78-8

Basic information

• Product Name: 2-(isopropylamino)isonicotinonitrile
• Synonyms: 2-(isopropylamino)isonicotinonitrile
• CAS NO: 127680-78-8
• Molecular Formula: C₉H₁₁N₃
• Molecular Weight: 161
• Mol File: 127680-78-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(isopropylamino)isonicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(isopropylamino)isonicotinonitrile(127680-78-8)
• EPA Substance Registry System: 2-(isopropylamino)isonicotinonitrile(127680-78-8)

Safety Data

• Hazardous Substances Data: 127680-78-8(Hazardous Substances Data)

Usage

General Description

2-(isopropylamino)isonicotinonitrile, also known as ipanicotine, is a chemical compound with the molecular formula C11H15N3. It is a derivative of isonicotinonitrile and contains an isopropylamino group. It is commonly used as an intermediate in the synthesis of pharmaceuticals, specifically in the production of drugs targeting cardiovascular, respiratory, and central nervous system disorders. Ipanicotine is also used as a key building block in the development of new chemical entities with potential therapeutic applications. It is a highly versatile and valuable compound in the pharmaceutical industry, with a wide range of potential uses in drug discovery and development.

Upstream product

• 33252-30-1 2-chloro-4-pyridinenitrile 
• 75-31-0 isopropylamine 
• 29181-50-8 2,4-Dicyanopyridine 

Relevant articles and documents

3-AMINO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES

Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.

Discovery of an N-(2-aminopyridin-4-ylmethyl)nicotinamide derivative: A potent and orally bioavailable NCX inhibitor

Ca2+ overload in myocardial cells is responsible for arrhythmia. Sodium-calcium exchanger (NCX) inhibitors are more effective than sodium-hydrogen exchanger (NHE) inhibitors with regard to modulation of Ca 2+ overload, because NCX inhibitors can directly inhibit the influx of Ca2+ into cells. NCX is an attractive target for the treatment of heart failure and ischemia-reperfusion. We have designed and synthesized a series of N-(2-aminopyridin-4-ylmethyl)nicotinamide derivatives, based on compound 5. We have discovered a novel NCX inhibitor (23h) with an IC 50 value of 0.12 μM against reverse NCX. The inhibitory activities of our NCX inhibitors against cytochrome P450 were also evaluated. The effects on heart failure and the pharmacokinetic profile of compound 23h are discussed.

A Study of the Photochemically Induced Reaction of Pyridine-2,4-dicarbonitrile with Primary and Secondary Amines. A Direct Synthesis of Aminocyanopyridines

A novel synthesis of alkylaminopyridinecarbonitriles by a photoinitiated substitution reaction between pyridine-2,4-dicarbonitrile and certain amines is described.The mechanism is discussed.