127680-90-4

Basic information

• Product Name: 2-(morpholin-4-yl)pyridine-4-carbonitrile
• Synonyms: 2-(morpholin-4-yl)pyridine-4-carbonitrile
• CAS NO: 127680-90-4
• Molecular Weight: 189.217
• Mol File: 127680-90-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(morpholin-4-yl)pyridine-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(morpholin-4-yl)pyridine-4-carbonitrile(127680-90-4)
• EPA Substance Registry System: 2-(morpholin-4-yl)pyridine-4-carbonitrile(127680-90-4)

Safety Data

• Hazardous Substances Data: 127680-90-4(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 29181-50-8 2,4-Dicyanopyridine 
• 19235-89-3 4-chloro-pyridine-2-carbonitrile 

Relevant articles and documents

4-Substituted picolinohydrazonamides as a new class of potential antitubercular agents

The series of new 4-substituted picolinohydrazonamides were synthesized (6-25) and evaluated for tuberculostatic activity. Compounds having a hydrophilic cyclic amine such as morpholine and pyrrolidine at the end of the thiosemicarbazide chain, exhibited the highest antimycobacterial activity. The antimycobacterial activity of compounds 6, 11, and 15 (MIC 0.4–0.8 μg/mL) was higher than that of reference drugs. Moreover, derivative 15 exhibited lower activity against other tested microorganism such as bacteria gram-positive, gram-negative or fungi. Thus, this compound is characterized by the selectivity of antimicrobial activity. Antiproliferative study conducted against human dermal fibroblasts (HDF) and mouse melanoma cell line (B16-F10) revealed low cytotoxicity of compound 15. Conducted research allowed to identify compound 15 as leading for further research.