127680-90-4Relevant academic research and scientific papers
4-Substituted picolinohydrazonamides as a new class of potential antitubercular agents
Krause, Malwina,Foks, Henryk,Ziembicka, Dagmara,Augustynowicz-Kope?, Ewa,G?ogowska, Agnieszka,Korona-G?owniak, Izabela,Bojanowski, Krzysztof,Siluk, Danuta,Gobis, Katarzyna
, (2020/02/15)
The series of new 4-substituted picolinohydrazonamides were synthesized (6-25) and evaluated for tuberculostatic activity. Compounds having a hydrophilic cyclic amine such as morpholine and pyrrolidine at the end of the thiosemicarbazide chain, exhibited the highest antimycobacterial activity. The antimycobacterial activity of compounds 6, 11, and 15 (MIC 0.4–0.8 μg/mL) was higher than that of reference drugs. Moreover, derivative 15 exhibited lower activity against other tested microorganism such as bacteria gram-positive, gram-negative or fungi. Thus, this compound is characterized by the selectivity of antimicrobial activity. Antiproliferative study conducted against human dermal fibroblasts (HDF) and mouse melanoma cell line (B16-F10) revealed low cytotoxicity of compound 15. Conducted research allowed to identify compound 15 as leading for further research.
A Study of the Photochemically Induced Reaction of Pyridine-2,4-dicarbonitrile with Primary and Secondary Amines. A Direct Synthesis of Aminocyanopyridines
Bernardi, Rosanna,Caronna, Tullio,Morrocchi, Sergio,Ursini, Maurizio,Vittimberga, Bruno M.
, p. 97 - 100 (2007/10/02)
A novel synthesis of alkylaminopyridinecarbonitriles by a photoinitiated substitution reaction between pyridine-2,4-dicarbonitrile and certain amines is described.The mechanism is discussed.
