127716-27-2Relevant academic research and scientific papers
A CONVENIENT SYNTHESIS OF 4-SUBSTITUTED-5-NITROIMIDAZOLE BUILDING BLOCKS
Crozet, Michel P.,Vanelle, Patrice,Jentzer, Olivier,Kaafarani, Mustapha
, p. 7 - 14 (2007/10/02)
The nitration of 1,2-dimethylimidazoles bearing at the C4 position a chain with a tertiary alcohol or a terminal alkene gives rise to 5-nitroimidazoles in which the side chains are converted in β-nitroalcohols.These compounds treated with base to splitt off nitromethane anion afford ketones.This represents a preparatively useful and convenient route to new 4-substituted 5-nitroimidazoles.
Heterocyclic radical ion substitution: V. Comparison between the reaction of 1,2-dimethyl-(chloroethyl)-4-nitro-5-imidazole and the e-nitrobenzyl system
Crozet,Vanelle,Jentzer,Maldonado
, p. 1269 - 1270 (2007/10/02)
The first example of radical-anion substitution (S(RN)1) involving a nitroimidazole compound in which the nitro group is ortho to the side-chain at which substitution occurs is described. This process is more effective in 5-nitroimidazole than in o-nitrobenzyle series.
