127717-18-4

Usage

Uses

Used in Pharmaceutical Research and Development:
Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate is used as a building block for the synthesis of novel drug candidates. Its structure and potential biological activities make it a valuable compound for further exploration in the development of new pharmaceuticals.
Used in Drug Discovery:
Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate is used as a potential candidate for drug discovery. It may exhibit anticancer, anti-inflammatory, and antiviral properties, making it a promising chemical for the development of new therapeutic agents.
Used in Anticancer Applications:
Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate is used as a potential anticancer agent. Its biological activities and structure make it a promising compound for the development of new cancer treatments.
Used in Anti-inflammatory Applications:
Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate is used as a potential anti-inflammatory agent. Its potential biological activities make it a promising compound for the development of new treatments for inflammatory conditions.
Used in Antiviral Applications:
Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate is used as a potential antiviral agent. Its potential biological activities make it a promising compound for the development of new treatments for viral infections.

Upstream product

• 55899-02-0 3-methyl-N-aminopyridinium mesitylenesulfonate 
• 922-67-8 propynoic acid methyl ester 

Downstream Products

• 139452-21-4 6-methylpyrazolo[1,5-a]pyridine-3-carboxylic acid 

Relevant academic research and scientific papers

Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors

A structure-activity relationship study for a 2-chloroanilide derivative of pyrazolo[1,5-a]pyridine revealed that increased EphB3 kinase inhibitory activity could be accomplished by retaining the 2-chloroanilide and introducing a phenyl or small electron donating substituents to the 5-position of the pyrazolo[1,5-a]pyridine. In addition, replacement of the pyrazolo[1,5-a]pyridine with imidazo[1,2-a]pyridine was well tolerated and resulted in enhanced mouse liver microsome stability. The structure-activity relationship for EphB3 inhibition of both heterocyclic series was similar. Kinase inhibitory activity was also demonstrated for representative analogs in cell culture. An analog (32, LDN-211904) was also profiled for inhibitory activity against a panel of 288 kinases and found to be quite selective for tyrosine kinases. Overall, these studies provide useful molecular probes for examining the in vitro, cellular and potentially in vivo kinase-dependent function of EphB3 receptor.

Acid-Catalyzed Reactions of 3-(Hydroxymethyl)- and 3-(1-Hydroxyethyl)pyrazolopyridines

Treatment of 3-(hydroxymethyl)pyrazolopyridines with trifluoroacetic acid in refluxing dichloromethane led to the formation of bis(pyrazolopyrid-3-yl)methanes or bis pyrid-3-yl)>methyl ethers depending upon the concentration of trifluoroacetic acid.In contrast, similar treatment of 3-(1-hydroxyethyl)pyrazolopyridines gave a mixture of 3-vinylpyrazolopyridines and 1,3-bis(pyrazolopyrid-3-yl)-1-butenes.