127717-18-4

Basic information

• Product Name: Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate
• Synonyms: Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate
• CAS NO: 127717-18-4
• Molecular Formula: C10H10N2O2
• Molecular Weight: 190.1986
• Mol File: 127717-18-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 100-101 °C(Solv: hexane (110-54-3))
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 0.88±0.30(Predicted)
• CAS DataBase Reference: Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate(127717-18-4)
• EPA Substance Registry System: Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate(127717-18-4)

Safety Data

• Hazardous Substances Data: 127717-18-4(Hazardous Substances Data)

Usage

General Description

Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate is a chemical compound with the molecular formula C10H9N3O2. It is a pyrazolopyridine derivative, which is often used in pharmaceutical research and development. Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate is known for its potential biological activities, especially in the field of drug discovery. It may exhibit anticancer, anti-inflammatory, and antiviral properties, and its structure makes it a valuable building block for the synthesis of novel drug candidates. Methyl 6-methylpyrazolo[1,5-a]pyridine-3-carboxylate has been the subject of various studies and is considered a promising chemical for further exploration in the development of new pharmaceuticals.

Upstream product

• 55899-02-0 3-methyl-N-aminopyridinium mesitylenesulfonate 
• 922-67-8 propynoic acid methyl ester 

Downstream Products

• 139452-21-4 6-methylpyrazolo[1,5-a]pyridine-3-carboxylic acid 

Relevant articles and documents

Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors

A structure-activity relationship study for a 2-chloroanilide derivative of pyrazolo[1,5-a]pyridine revealed that increased EphB3 kinase inhibitory activity could be accomplished by retaining the 2-chloroanilide and introducing a phenyl or small electron donating substituents to the 5-position of the pyrazolo[1,5-a]pyridine. In addition, replacement of the pyrazolo[1,5-a]pyridine with imidazo[1,2-a]pyridine was well tolerated and resulted in enhanced mouse liver microsome stability. The structure-activity relationship for EphB3 inhibition of both heterocyclic series was similar. Kinase inhibitory activity was also demonstrated for representative analogs in cell culture. An analog (32, LDN-211904) was also profiled for inhibitory activity against a panel of 288 kinases and found to be quite selective for tyrosine kinases. Overall, these studies provide useful molecular probes for examining the in vitro, cellular and potentially in vivo kinase-dependent function of EphB3 receptor.