1277183-26-2Relevant academic research and scientific papers
A stereoselective approach to γ-functionalized carbonyls exploiting the Cu-promoted SN2′ reaction
Bond, Eric,Beausoleil, Anne-Marie,Howell, Jennifer,Wong, Alicia,Robichaud, Joel
, p. 2488 - 2493 (2011/06/24)
While several efficient processes exist to effect the stereoselective creation of carbon-carbon bonds in the α- and β-position of carbonyls, functionalization of the γ-position is much more challenging. We disclose an alternative methodology exploiting the Cu-promoted S N2′ reaction to achieve the addition of various nucleophiles upon the allylic lactones 5a-d which lead to the generation of the desired γ-functionalized α,β-unsaturated aldehydes 6 following in situ hydrolysis.
