1277185-06-4

Upstream product

• 3650-78-0 methyl (E)-4-bromocinnamate 
• 1200-07-3 trans-4-bromocinnamic acid 
• 105515-33-1 (2E)-3-(4-bromophenyl)prop-2-en-1-ol 
• 96090-12-9 1-(4-bromophenyl)-1-propen-3-yl bromide 
• 109-77-3 malononitrile 
• 184360-96-1 (E)-4-(4-bromophenyl)-3-butenoic acid 
• 1310810-15-1 methyl (E)-4-(4’-bromophenyl)but-3-enoate 
• 1190898-63-5 (E)-1-bromo-4-(4-bromobut-1-enyl)benzene 

Downstream Products

• 1277184-91-4 (3R,4aS,9S,9aR)-9-(4-bromophenyl)-7-nitro-3-propyl-1,2,3,4,4a,9,9a,10-octahydroacridine-2,2(1H)-dicarbonitrile 
• 1277185-04-2 (3R,4aS,9S,9aR)-7-bromo-9-(4-bromophenyl)-3-propyl-1,2,3,4,4a,9,9a,10-octahydroacridine-2,2(9H)-dicarbonitrile 
• 1296208-11-1 (3S,3aS,6R,7aR)-3-(4-bromophenyl)-6-ethyl-1-phenylhexahydrobenzo[c]isoxazole-5,5(3H)-dicarbonitrile 

Relevant academic research and scientific papers

Optically active bicyclic N-heterocycles by organocatalytic asymmetric Michael addition/cyclization sequences

Highly stereoselective one-pot syntheses of various optically active N-heterocyclic bicycles have been developed. The protocols are based on an organocatalytic, asymmetric Michael addition followed by a condensation/ cycloaddition sequence to furnish aziridine carbonyls, β-lactams, or octahydrobenzo[c]isoxazoles depending on the reaction conditions and applied nucleophiles. Copyright

An asymmetric organocatalytic one-pot strategy to octahydroacridines

An elegant sequence: An efficient method for the formation of octahydroacridines provides high yields and a high level of stereogenic control, and displays great tolerance towards different aldehydes, anilines, and nucleophiles (see scheme; TMS=trimethyls