1277193-23-3

Upstream product

• 1145873-64-8 6-chloro-5,7,8-trimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 1277192-86-5 6-bromo-5,7,8-trimethyl-2H-1,4-benzoxazin-3(4H)-one 

Relevant academic research and scientific papers

Divergent synthesis of 2,6-diaryl-substituted 5,7,8-trimethyl-1,4- benzoxazines via microwave-promoted palladium-catalyzed Suzuki-Miyaura cross coupling and biological evaluation

An efficient palladium-catalyzed Suzuki-Miyaura cross-coupling protocol effected in a mixture of DME/water (2:1) enables the reaction of sterically hindered and electron rich 6-chloro or 6-bromo-1,4-benzoxazines(ones) with a variety of aryl, vinyl or alkylboronic acids. Coupling is effected with catalyst loading of 5 mol % using sealed-vessel microwave processing. The resulting compounds exhibit potent activity against Toxoplasma gondii tachyzoite proliferation.