127726-65-2Relevant academic research and scientific papers
The Chemistry of Pyrimidinethiols. III The Synthesis of Some Substituted Pyrimidinethiols and Some Thiazolopyrimidines
Harnden, Michael R.,Hurst, Derek T.
, p. 55 - 62 (2007/10/02)
The preparation of a number of pyrimidinethiols and (substituted)thiopyrimidines has been carried out.The reaction of 5-acetylamino-2-aminopyrimidine-4,6-diol with phosphorus pentasulfide in pyridine gave 5-amino-2-methylthiazolopyrimidine-7-thiol which was used to prepare several additional novel pyrimidine derivatives.Hydrolysis of the 4-carboxymethylthio derivative by using 5 M hydrochloric acid gave 2,5-diamino-6-mercaptopyrimidin-4-ol hydrochloride whilst hydrolysis of 2-methyl-7-methylthiothiazolopyrimidin-5-amine gave the corresponding 4-hydroxy derivative.Several 4-arenecarbonylmethylthio derivatives were recovered unchanged from such hydrolysis reactions.
