127733-36-2

Basic information

• Product Name: 3'-trifluoromethylacetophenone oxime O-methyl ether
• Synonyms: 3'-trifluoromethylacetophenone oxime O-methyl ether
• CAS NO: 127733-36-2
• Molecular Weight: 217.191
• Mol File: 127733-36-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3'-trifluoromethylacetophenone oxime O-methyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-trifluoromethylacetophenone oxime O-methyl ether(127733-36-2)
• EPA Substance Registry System: 3'-trifluoromethylacetophenone oxime O-methyl ether(127733-36-2)

Safety Data

• Hazardous Substances Data: 127733-36-2(Hazardous Substances Data)

Upstream product

• 593-56-6 N-methoxylamine hydrochloride 
• 349-76-8 3'-(trifluoromethyl)acetophenone 

Downstream Products

• 127733-49-7 2-{[(E)-(S)-1-(3-Trifluoromethyl-phenyl)-ethylimino]-methyl}-phenol 
• 1448171-31-0 C₁₅H₁₉F₃N₂O 
• 202664-53-7 2-fluoro-5-trifluoromethyl-acetophenone 
• 127852-21-5 (S)-α-(m-(trifluoromethyl)phenyl)ethylamine 
• 127852-30-6 (R)-α-(m-(trifluoromethyl)phenyl)ethylamine 

Relevant articles and documents

Nitrate promoted mild and versatile Pd-catalysed C(sp2)-H oxidation with carboxylic acids

A nitrate-promoted Pd-catalysed mild cross-dehydrogenative C(sp2)-H bond oxidation of oximes or azobenzenes with diverse carboxylic acids has been developed. In contrast to the previous catalytic systems, this protocol features mild conditions (close to room temperature for most cases) and a broad substrate scope (up to 64 examples), thus constituting a versatile method to directly prepare diverse O-aryl esters. Moreover, the superiority of the nitrate additive in this mild transformation was further determined by experimental and computational evidence.

IMPROVED METHOD FOR PRODUCING SPECIFIC OXIMES AND OXIMETHERS

Method for preparing certain oximes and oxime O-methyl ethers by reacting poorly water-soluble carbonyl compounds with salts of hydroxylamine or hydroxylamine O-methyl ether or the free base of hydroxylamine in the presence of certain phosphoric esters or salts thereof of the formula (I) wherein R1, R2 and X are defined as specified in the description.

[Cp*RhCl2]2-catalyzed ortho-C-H bond amination of acetophenone o-methyloximes with primary N-chloroalkylamines: Convenient synthesis of N-alkyl-2-acylanilines

Rh(iii)-catalyzed aromatic C-H amination of acetophenone o-methyloximes with primary N-chloroalkylamines was developed, and the arylamine products were obtained in up to 92% yield. The reaction probably involves rate-limiting electrophilic C-H bond cleavage (kH/kD = 2).