127733-46-4 Usage
General Description
(R)-1-[2-(Trifluoromethyl)phenyl]ethylamine, also known as R-(-)-2-Amino-1-(2-trifluoromethylphenyl)ethanol, is a chemical compound with the molecular formula C9H11F3N. It is an amine compound that contains a trifluoromethyl group and a phenyl ring. This chemical is a chiral compound, meaning it has a non-superimposable mirror image, and the (R) form is the enantiomer with the configuration where the molecule is oriented in a clockwise direction. (R)-1-[2-(Trifluoromethyl)phenyl]ethylamine is used in the pharmaceutical industry for the synthesis of various drug molecules, and it also has potential applications in other fields such as agrochemicals and materials science. (R)-1-[2-(Trifluoromethyl)phenyl]ethylamine poses a risk of skin and eye irritation and may be harmful if swallowed, inhaled, or absorbed through the skin. Therefore, appropriate safety measures should be taken when handling it.
Check Digit Verification of cas no
The CAS Registry Mumber 127733-46-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,7,3 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 127733-46:
(8*1)+(7*2)+(6*7)+(5*7)+(4*3)+(3*3)+(2*4)+(1*6)=134
134 % 10 = 4
So 127733-46-4 is a valid CAS Registry Number.
127733-46-4Relevant articles and documents
Stereoselective amination of racemic sec-alcohols through sequential application of laccases and transaminases
Martínez-Montero, Lía,Gotor, Vicente,Gotor-Fernández, Vicente,Lavandera, Iván
, p. 474 - 480 (2017/06/23)
A one-pot/two-step bienzymatic asymmetric amination of secondary alcohols is disclosed. The approach is based on a sequential strategy involving the use of a laccase/TEMPO catalytic system for the oxidation of alcohols into ketone intermediates, and their following transformation into optically enriched amines by using transaminases. Individual optimizations of the oxidation and biotransamination reactions have been carried out, studying later their applicability in a concurrent process. Therefore, 17 racemic (hetero) aromatic sec-alcohols with different substitutions in the aromatic ring have been converted into enantioenriched amines with good to excellent selectivities (90-99% ee) and conversion values (67-99%). The scalability of the process was also demonstrated when two different amine donors were used in the transamination step, such as isopropylamine and cis-2-buten-1,4-diamine. Satisfyingly, both sacrificial amine donors can shift the equilibrium toward the amine formation, leading to the corresponding isolated enantioenriched amines with good to excellent results.
