127757-91-9

Basic information

• Product Name: Regramostim
• Synonyms: CSF-2;Regramostim;Colony-stimulating factor 2 (human clone pcsf-1 protein moiety reduced), glycoform gmc 89-107;Regramostime;Regramostime [inn-french];Regramostimum;Regramostimum [inn-latin];GM-CSF from mouse
• CAS NO: 127757-91-9
• Molecular Weight: 0
• Mol File: 127757-91-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: Regramostim(CAS DataBase Reference)
• NIST Chemistry Reference: Regramostim(127757-91-9)
• EPA Substance Registry System: Regramostim(127757-91-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 127757-91-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 127757-91-9 differently. You can refer to the following data:
1. Antineutropenic; hematopoietic stimulant.
2. GM-CSF (granulocyte-macrophage colony-stimulating factor) mouse has been used to check effect of GM-CSF on retinal ganglion cell neurite outgrowth in the retinal explants.

General Description

GM-CSF (granulocyte-macrophage colony-stimulating factor, also referred to as CSF2) is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. Recombinant murine GM-CSF is a 14.2kDa globular protein consisting of 124 amino acids residues. The human and murine molecules are species-specific and exhibit no cross-species reactivity.

Biochem/physiol Actions

GM-CSF (granulocyte-macrophage colony-stimulating factor, also referred to as CSF2) is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It enhances neutrophil migration. GM-CSF plays a crucial role in inflammatory and autoimmune diseases. In neutrophils, it promotes the expression of TLR2 (Toll-like receptor) and TLR2-associated interleukin 8 responses, thereby eliminating microbial attack.