127761-05-1

Basic information

• Product Name: methyl 4-hydroxy-5-iodo-2,3-dimethoxy-6-methylbenzoate
• Synonyms: methyl 4-hydroxy-5-iodo-2,3-dimethoxy-6-methylbenzoate
• CAS NO: 127761-05-1
• Molecular Formula: C₁₁H₁₃IO₅
• Molecular Weight: 0
• Mol File: 127761-05-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 384°Cat760mmHg
• Flash Point: 186°C
• Appearance: /
• Density: 1.66g/cm³
• Vapor Pressure: 1.92E-06mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: methyl 4-hydroxy-5-iodo-2,3-dimethoxy-6-methylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-hydroxy-5-iodo-2,3-dimethoxy-6-methylbenzoate(127761-05-1)
• EPA Substance Registry System: methyl 4-hydroxy-5-iodo-2,3-dimethoxy-6-methylbenzoate(127761-05-1)

Safety Data

• Hazardous Substances Data: 127761-05-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H13IO5/c1-5-6(11(14)17-4)9(15-2)10(16-3)8(13)7(5)12/h13H,1-4H3

Upstream product

• 127725-09-1 methyl 4-benzyloxy-2,3-dimethoxy-6-methylbenzoate 
• 127725-08-0 methyl 4-benzyloxy-2,3-dihydroxy-6-methylbenzoate 
• 150650-44-5 5-<(tert-butyldimethylsilyl)oxy>-2,6-diiodo-3,4-dimethoxytoluene 
• 115592-75-1 2,6-diiodo-3,4,5-trimethoxytoluene 
• 115592-76-2 5-hydroxy-2,6-diiodo-3,4-dimethoxytoluene 
• 6443-69-2 3,4,5-trimethoxytoluene 
• 190653-31-7 4-Formyl-2,3-dimethoxy-6-methyl-benzoic acid methyl ester 
• 150650-45-6 methyl 4-<(tert-butyldimethylsilyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoate 
• 115592-78-4 4-Benzyloxymethoxy-3-iodo-5,6-dimethoxy-2-methyl-benzoic acid methyl ester 
• 127725-10-4 methyl 4-hydroxy-2,3-dimethoxy-6-methylbenzoate 

Downstream Products

• 130851-51-3 4-Benzyloxy-3-iodo-5,6-dimethoxy-2-methyl-thiobenzoic acid S-((2R,3S,4S,6S)-4-hydroxy-6-methoxy-2-methyl-tetrahydro-pyran-3-yl) ester 
• 130851-50-2 4-Benzyloxy-3-iodo-5,6-dimethoxy-2-methyl-benzoyl chloride 
• 130851-49-9 4-Benzyloxy-3-iodo-5,6-dimethoxy-2-methyl-benzoic acid 
• 131675-60-0 3-Iodo-5,6-dimethoxy-4-((2S,3R,4R,5S,6S)-4-methoxy-6-methyl-3,5-bis-triethylsilanyloxy-tetrahydro-pyran-2-yloxy)-2-methyl-thiobenzoic acid S-phenyl ester 
• 131675-33-7 4-((2S,3R,4R,5S,6S)-3,5-Dihydroxy-4-methoxy-6-methyl-tetrahydro-pyran-2-yloxy)-3-iodo-5,6-dimethoxy-2-methyl-thiobenzoic acid S-phenyl ester 
• 150650-46-7 4-<<3-O-methyl-2,4-bis-O-(triethylsilyl)-α-L-rhamnopyranosyl>oxy>-5-iodo-2,3-dimethoxy-6-methylbenzaldehyde 
• 131675-58-6 methyl 4-<<3-O-methyl-2,4-bis-O-(triethylsilyl)-α-L-rhamnopyranosyl>oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoate 
• 129834-74-8 4-<<3-O-methyl-2,4-bis-O-(triethylsilyl)-α-L-rhamnopyranosyl>oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoic acid 
• 129834-75-9 4-<(6-deoxy-3-O-methyl-2,4-O,O-bis(triethylsilyl)-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoic acid chloride 
• 131675-59-7 4-<<3-O-methyl-2,4-bis-O-(triethylsilyl)-α-L-rhamnopyranosyl>oxy>-5-iodo-2,3-dimethoxy-6-methylbenzyl alcohol 
• 130851-56-8 methyl 4-<<3-O-methyl-α-L-rhamnopyranosyl>oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoate 
• 153693-41-5 2-((tert-butyldiphenylsilyloxy)methyl)-5-<(4-O-acetyl-6-deoxy-3-O-methyl-2-O-pivaloyl-α-L-mannopyranosyl)oxy>-3,4-dimethoxy-6-iodotoluene 
• 153693-42-6 4-<(-4-O-acetyl-6-deoxy-3-O-methyl-2-O-pivaloyl-α-L-mannopyranosyl)oxy>-2,3-dimethoxy-5-iodo-6-methylbenzoic acid 
• 153693-30-2 bis(ethyloxy)phosphinoyl-4-<(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy>-5-iodo-2,3-dimethoxy-6-methylbenzoate 

Relevant articles and documents

Synthesis of the aromatic unit of calicheamicin γ1 I

Vanillin and piperonal are each converted into methyl 2,3-dimethoxy-6-methyl-4-(prop-2-enyl)benzoate 12, and this is then elaborated into methyl 4-hydroxy-3-iodo-5,6-dimethoxy-2-methylbenzoate 24, which represents the aromatic unit of calicheamicin γ1I.

SYNTHESES OF 4-HYDROXY-5-IODO-2,3-DIMETHOXY-6-METHYLBENZOIC ACID AND 5-BROMO-4-HYDROXY-2,3-DIMETHOXY-6-METHYLBENZOIC ACID - AROMATIC CONSTITUENTS OF THE CALICHEMICINS

4-Hydroxy-5-iodo-2,3-dimethoxy-6-methylbenzoic acid (1) and 5-bromo-4-hydroxy-2,3-dimethoxy-6-methylbenzoic acid (2) are the polysubstituted aromatic carboxylic acids found in calichemicin antibiotics.The title compounds are synthesized on preparative sca