127801-02-9Relevant articles and documents
Synthesis of Cationic Metalloporphyrin Precursors Related to the Design of DNA Cleavers
Casas, Christiane,Saint-Jalmes, Bernadette,Loup, Christophe,Lacey, C. Jeffrey,Meunier, Bernard
, p. 2913 - 2917 (1993)
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Mitochondria-targeting Pt/Mn porphyrins as efficient photosensitizers for magnetic resonance imaging and photodynamic therapy
Yang, Mengqian,Deng, Jingran,Guo, Ding,Sun, Qi,Wang, Zejiang,Wang, Kai,Wu, Fengshou
, p. 189 - 195 (2019)
Photodynamic therapy (PDT), as a minimally invasive and highly efficient anticancer approach, has received extensive attention. However, the search for more effective and less toxic photodynamic photosensitizers with good biocompatibility and high specifi
Water-soluble porphyrin-phosphonate conjugates as potential photodynamic therapy photosensitizers
Lu, Yunguo,Chen, Zhihang,Yu, Bingqiong,Yan, Kun,Li, Zaoying
, p. 1039 - 1045 (2015)
Two novel water-soluble porphyrin-phosphonate conjugates were synthesized and characterized. Although both conjugates showed significant potential in photodynamic therapy, the variety of their structure induced the obvious differences in the binding manne
The synthesis and photodynamic properties of meso-substituted, cationic porphyrin derivatives in HeLa cells
Peng, Cheng-Liang,Lai, Ping-Shan,Chang, Cheng-Chung,Lou, Pei-Jen,Shieh, Ming-Jium
, p. 140 - 147 (2010)
A series of asymmetric porphyrins with varying substituents, such as 4-hydrophenyl and N-methyl-4-pyridyl, were synthesized and characterized and their cell uptake, intracellular localization, cytotoxicities and phototoxicities were evaluated in vitro. The most phototoxic of the porphyrins synthesized, 5,10-di-(N-methyl-4-pyridyl)-15,20-(4-hydroxyphenyl)-21,23H-porphyrin, which was mainly localized in the mitochondria and displayed low levels of dark toxicity toward human cancer HeLa cells, offers potential application in photodynamic therapy.