127801-02-9

Upstream product

• 139547-50-5 5-(4-methoxyphenyl)-10,15,20-tri(N-methylpyridinium-4-yl)porphyrin triiodide 
• 26725-51-9 4-hydroxybenzotriazole 
• 872-85-5 pyridine-4-carbaldehyde 
• 109-97-7 pyrrole 
• 123-08-0 4-hydroxy-benzaldehyde 
• 139547-50-5 5-(4-methoxyphenyl)-10,15,20-tris(4-pyridyl)porphyrin 

Relevant academic research and scientific papers

Novel porphyrin-psoralen conjugates: Synthesis, DNA interaction and cytotoxicity studies

A Cu(i)-catalyzed azide-alkyne cycloaddition reaction (CuAAC) has been utilized to prepare novel triazole-linked cationic porphyrin-psoralen conjugates that exhibited significant photocytotoxicity against A549 cancer cells (IC 50 = 84 nM).

Mitochondria-targeting Pt/Mn porphyrins as efficient photosensitizers for magnetic resonance imaging and photodynamic therapy

Photodynamic therapy (PDT), as a minimally invasive and highly efficient anticancer approach, has received extensive attention. However, the search for more effective and less toxic photodynamic photosensitizers with good biocompatibility and high specifi

Novel porphyrin-daunomycin hybrids: Synthesis and preferential binding to G-quadruplexes over i-motif

Encouraged by the enormous importance attributed to the structure and function of human telomeric DNA, herein we focused our attention on the interaction of a serious of newly prepared porphyrin-daunomycin (Por-DNR) hybrids with the guanine-rich single-strand oligomer (G4) and the complementary cytosine-rich strand (i-motif). Various spectral methods such as absorption and fluorescence titration, surface-enhanced Raman and circular dichroism spectrum were integrated in the experiment and it was found that these Por-DNR hybrids could serve as prominent molecules to recognize G4 and i-motif. What is more, interesting results were obtained that the hybrids with longer flexible links are more favorable in binding with both G4 and i-motif than the hybrid with shorter linkage. These Por-DNR hybrids may help to develop new ideas in the research of human telomeric DNA with small molecules.

Water-soluble porphyrin-phosphonate conjugates as potential photodynamic therapy photosensitizers

Two novel water-soluble porphyrin-phosphonate conjugates were synthesized and characterized. Although both conjugates showed significant potential in photodynamic therapy, the variety of their structure induced the obvious differences in the binding manne

Synthesis, DNA-binding, and photocleavage properties of a serious of porphyrin-daunomycin hybrids

It is widely accepted that the pharmacological activities of anthracyclines antitumor agents express when the quinone-containing chromophore intercalates into base pairs of the duplex DNA. We have successfully synthesized and investigated the DNA-interactions of hybrids composed with quinone chromophore and cationic porphyrin. Herein, a clinic anticancer drug, daunomycin, is introduced to the porphyrin hybrids through different lengths of amide alkyl linkages, and their interactions and cleavage to DNA were studied compared with the previous porphyrin-quinone hybrids. Spectral results and the determined binding affinity constants (Kb) show that the attachment of daunomycin to porphyrin could improve the DNA-binding and photocleaving abilities. The porphyrin-daunomycin hybrids may find useful employment in investigating the ligand-DNA interaction.

The synthesis and photodynamic properties of meso-substituted, cationic porphyrin derivatives in HeLa cells

A series of asymmetric porphyrins with varying substituents, such as 4-hydrophenyl and N-methyl-4-pyridyl, were synthesized and characterized and their cell uptake, intracellular localization, cytotoxicities and phototoxicities were evaluated in vitro. The most phototoxic of the porphyrins synthesized, 5,10-di-(N-methyl-4-pyridyl)-15,20-(4-hydroxyphenyl)-21,23H-porphyrin, which was mainly localized in the mitochondria and displayed low levels of dark toxicity toward human cancer HeLa cells, offers potential application in photodynamic therapy.

A porphyrin-pyranine dyad for ratiometric fluorescent sensing of intracellular pH

The detection of intracellular pH (pHi) by fluorescence imaging is highly desired for cell biology and medical science. In this study, we developed a FRET-based porphyrin-pyranine dyad (Por-Py 1) composed of a pyranine moiety as the energy dono

Synthesis, DNA-Binding, and Photocleavage Properties of a Serious of Porphyrin-Daunomycin Hybrids

It is widely accepted that the pharmacological activities of anthracyclines antitumor agents express when the quinone-containing chromophore intercalates into base pairs of the duplex DNA. We have successfully synthesized and investigated the DNA-interactions of hybrids composed with quinone chromophore and cationic porphyrin. Herein, a clinic anticancer drug, daunomycin, is introduced to the porphyrin hybrids through different lengths of amide alkyl linkages, and their interactions and cleavage to DNA were studied compared with the previous porphyrin-quinone hybrids. Spectral results and the determined binding affinity constants (Kb) show that the attachment of daunomycin to porphyrin could improve the DNA-binding and photocleaving abilities. The porphyrin-daunomycin hybrids may find useful employment in investigating the ligand-DNA interaction.

Remarkable photocytotoxicity of a novel triazole-linked cationic porphyrin-β-carboline conjugate

Employing a click chemistry approach we have synthesized a novel triazole-linked cationic porphyrin-β-carboline conjugate which exhibited remarkable photocytotoxicity against the A549 cancer cell line (IC50 = 60 nM).