127813-10-9Relevant academic research and scientific papers
1,2-Addition of dimethyl(phenyl)silyllithium to cyclic α,β-unsaturated ketones and regiospecific generation of cyclic silyl enol ethers through Brook rearrangement of the 1,2-addition products
Koreeda,Koo
, p. 831 - 834 (2007/10/02)
A highly convenient two-step sequence for the regiospecific synthesis of cyclic silyl enol ethers has been developed involving the 1,2-addition of dimethyl(phenyl)silyllithium to cyclic α,β-unsaturated ketones followed by the treatment of the resulting silyl carbinols with a catalytic amount of NaH in THF at 25°C.
