127818-73-9

Basic information

• Product Name: 2-methyl-N¹-phenylbenzene-1,4-diamine
• Synonyms: 2-methyl-N¹-phenylbenzene-1,4-diamine
• CAS NO: 127818-73-9
• Molecular Weight: 198.268
• Mol File: 127818-73-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methyl-N¹-phenylbenzene-1,4-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-N¹-phenylbenzene-1,4-diamine(127818-73-9)
• EPA Substance Registry System: 2-methyl-N¹-phenylbenzene-1,4-diamine(127818-73-9)

Safety Data

• Hazardous Substances Data: 127818-73-9(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 7149-70-4 2-bromo-5-nitrotoluene 
• 62-53-3 aniline 
• 99-52-5 2-methyl-4-nitro-benzenamine 
• 16588-31-1 2-methyl-4-nitro-N-phenylaniline 

Relevant articles and documents

One-pot propagation of (Hetero)Arylamines: Modular synthesis of diverse Amino-di(hetero)arylamines

Formal propagation of (hetero)arylamine is achieved via a one-pot Buchwald–Hartwig C–N cross-coupling and nitro reduction sequence, enabling a rapid modular synthesis of diverse amino-di(hetero)arylamines from (hetero)arylamines and halogenated nitrobenzenes. Various functionalized aromatic amines with different electronic and steric environments can be efficiently prolongated to formally incorporate another arylamino fragments. This approach has been successfully applied in the synthesis of more than forty amino-di(hetero)arylamines. The applicability of this method has also been demonstrated in the synthesis of oligoanilines and the tyrosine-kinase inhibitor Imatinib.