127819-66-3Relevant academic research and scientific papers
Applications of carbon-nitrogen bond cleavage reaction: A synthesis/derivatisation of 11H-indeno[1,2-c]isoquinolines
Lal, Bansi,Gidwani, Ramesh M.
, p. 33 - 39 (2007/10/03)
Orthophosphoric acid HCOOH treatment of 3-(4,5-dimethoxy-2- vinylphenyl)-1(2H)-isoquinolinone 5a and 6,7-dimethoxy 3-(4,5-dimethoxy-2- vinylphenyl)-1(2H)-isoquinolinone 5b brings about cyclization to give the indeno[1,2-c]isoquinolines 6a and 6b. Reaction with POCl3 produces the chloro compounds. Hydrogenolysis gives the dechlorinated products 8a and 8b. Reaction of chloro derivatives with different mines gives the amino substituted 11H-indeno-[1,2-c]isoquinolines 9 and 10.
A Novel Base-Catalyzed Carbon-Nitrogen Bond Fission in Some Heterocycles
Lal, Bansi,Gidwani, Ramesh M.,Souza, Noel J. de
, p. 5117 - 5124 (2007/10/02)
Nitrogen heterocycles bearing a nonbasic nitrogen atom and other defined structural features as exemplified by 9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimidoisoquinoline-2,4-dione (1), 8-oxypseudopalmatine (22), 8-oxypseudoberberine (25), rutaecarpine (39), and related systems, on heating with excess sodium hydride in polar aprotic solvents, undergo a facile carbon-nitrogen bond cleavage reaction to give new nitrogen heterocycles with an arylvinyl group as one of the substituents.The nature, scope, postulated mechanism, and limitations of this novel carbon-nitrogen cleavage reaction are described.
