127827-48-9Relevant academic research and scientific papers
Thiyl radical promoted iron-catalyzed-selective oxidation of benzylic sp3 C-H bonds with molecular oxygen
Geng, Shasha,Xiong, Baojian,Zhang, Yun,Zhang, Juan,He, Yun,Feng, Zhang
, p. 12699 - 12702 (2019/10/28)
A ligand-free iron-catalyzed method for the oxygenation of benzylic sp3 C-H bonds by molecular oxygen (1 atm) using a thiyl radical as a cocatalyst has been developed. This transformation provides a facile access to amides, esters and ketones from readily accessible corresponding amines, ethers and alkanes. It features high regioselectivity, mild oxidative conditions and excellent functional group compatibility, providing good opportunities to the site-selective functionalization of complex molecules. Preliminary mechanistic studies suggest that this reaction may not undergo a benzylic cation intermediate pathway and the carbonyl oxygen atom in the products may be derived from molecular oxygen.
Intramolecular Hydroamidation of ortho-Vinyl Benzamides Promoted by Potassium tert-Butoxide/N,N-Dimethylformamide
Chen, Zhen-Yu,Wu, Liang-Yu,Fang, Hai-Sheng,Zhang, Ting,Mao, Zhi-Feng,Zou, Yong,Zhang, Xue-Jing,Yan, Ming
, p. 3894 - 3899 (2017/10/07)
An intramolecular hydroamidation of ortho-vinyl benzamides had been developed. The reaction was promoted efficiently by potassium tert-butoxide and N,N-dimethylformamide without the need for strong oxidants or transition-metal catalysts. A series of dihyd
A visible light photocatalytic cross-dehydrogenative coupling/dehydrogenation/6π-cyclization/oxidation cascade: Synthesis of 12-nitroindoloisoquinolines from 2-aryltetrahydroisoquinolines
Rusch, Fabian,Unkel, Lisa-Natascha,Alpers, Dirk,Hoffmann, Frank,Brasholz, Malte
supporting information, p. 8336 - 8340 (2015/06/02)
A visible light-induced photocatalytic dehydrogenation/6π-cyclization/oxidation cascade converts 1-(nitromethyl)-2-aryl-1,2,3,4-tetrahydroisoquinolines into novel 12-nitro-substituted tetracyclic indolo[2,1-a]isoquinoline derivatives. Various photocatalysts promote the reaction in the presence of air and a base, the most efficient being 1-aminoanthraquinone in combination with K3PO4. Further, the 12-nitroindoloisoquinoline products can be accessed directly from C1-unfunctionalized 2-aryl-1,2,3,4-tetrahydroisoquinolines by extending the one-pot protocol with a foregoing photocatalytic cross-dehydrogenative coupling reaction, resulting in a quadruple cascade transformation.
Reaction of N-Nitroaryl-1,2,3,4-tetrahydroisoquinoline Derivatives with Oxygen
Shawcross, A. P.,Stanforth, S. P.
, p. 367 - 369 (2007/10/02)
Heating N-4'-methyl-2'-nitrophenyl-1,2,3,4-tetrahydroisoquinoline (1) in the presence of oxygen gave both products derived from cleavage of the C8a-Cl bond and oxidation at the 1-position.Under similar conditions N-4'-nitrophenyl-1,2,3,4-tetrahydroisoquin
