127838-90-8

Basic information

• Product Name: C₁₀H₁₆N₃O₈S^(1-)
• Synonyms: C₁₀H₁₆N₃O₈S^(1-)
• CAS NO: 127838-90-8
• Molecular Weight: 338.318
• Mol File: 127838-90-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₀H₁₆N₃O₈S^(1-)(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₁₆N₃O₈S^(1-)(127838-90-8)
• EPA Substance Registry System: C₁₀H₁₆N₃O₈S^(1-)(127838-90-8)

Safety Data

• Hazardous Substances Data: 127838-90-8(Hazardous Substances Data)

Upstream product

• 299-36-5 ascorbate 
• 50-53-3 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine 

Downstream Products

• 50-53-3 chloropromazine cation radical 
• 63983-50-6 ascorbic acid radical anion 

Relevant articles and documents

Redox Reactions of Thiol Free Radicals with the Antioxidants Ascorbate and Chlorpromazine: Role in Radioprotection

The interaction of the thiyl radical from glutathione, GS*, and its corresponding peroxyl radical adduct, GSO2*, with the reducing agents, ascorbate and chlorpromazine, have been studied in aqueous solution at pH 5.0-5.5 using the technique of pulse radiolysis with spectrophotometric detection.The rate constants determined for interaction of GS* with ascorbate and chlorpromazine are 5.4 * 108 and 9.0 * 108 dm3 mol-1 respectively.The reaction is thought to proceed via an electron transfer process.Further, the redox potential of GS*/GSH at pH 5.0 is estimated to be 0.91 V.In the presence of different concentrations of oxygen, it has been established that GSO2*, as observed at 540 nm, interacts with ascorbate and chloropromazine by electron transfer with rate constants of 2.1 * 108 and 5.0 * 108 dm3 mol-1 s-1 respectively.From these kinetic observations it is inferred that GSO2* is a weaker oxidant than GS*.From these findings the role of these glutathione radicals should be taken into account when considering the biological role of thiols in oxidative damage in biological systems.