1278591-67-5

Basic information

• Product Name: 3-hydroxy-3-[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]butan-2-one
• Synonyms: 3-hydroxy-3-[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]butan-2-one
• CAS NO: 1278591-67-5
• Molecular Weight: 246.266
• Mol File: 1278591-67-5.mol

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-3-[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]butan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-3-[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]butan-2-one(1278591-67-5)
• EPA Substance Registry System: 3-hydroxy-3-[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]butan-2-one(1278591-67-5)

Safety Data

• Hazardous Substances Data: 1278591-67-5(Hazardous Substances Data)

Upstream product

• 73789-56-7 N-isocyaniminotriphenylphosphorane 
• 431-03-8 dimethylglyoxal 
• 99-04-7 m-Toluic acid 

Relevant articles and documents

The reaction of (N-isocyanimino)triphenylphosphorane with biacetyl in the presence of aromatic carboxylic acids: Efficient one-pot three-component reaction for the synthesis of 3-(5-aryl-1,3,4-oxadiazol-2-yl)-3-hydroxybutan-2- one derivatives

Reactions of biacetyl (=butane-2,3-dione) with (N-isocyanimino) triphenylphosphorane in the presence of aromatic carboxylic acids proceed smoothly at room temperature and under neutral conditions to afford 3-(5-aryl-1,3,4-oxadiazol-2-yl)-3-hydroxybutan-2-

Three-component reaction of N-isocyaniminotriphenylphosphorane (Ph 3PNNC), biacetyl, and a carboxylic acid in water

Reaction of N-isocyaniminotriphenylphosphorane with biacetyl in the presence of a carboxylic acid in water proceeds smoothly at RT (20-26°C) and neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction pr