127876-62-4

Basic information

• Product Name: N,N-dimethyl-2-[2-(phenylsulfanyl)phenyl]ethanamine
• Synonyms: N,N-dimethyl-2-[2-(phenylsulfanyl)phenyl]ethanamine
• CAS NO: 127876-62-4
• Molecular Formula: C16H19NS
• Molecular Weight: 257.39376
• Mol File: 127876-62-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N,N-dimethyl-2-[2-(phenylsulfanyl)phenyl]ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethyl-2-[2-(phenylsulfanyl)phenyl]ethanamine(127876-62-4)
• EPA Substance Registry System: N,N-dimethyl-2-[2-(phenylsulfanyl)phenyl]ethanamine(127876-62-4)

Safety Data

• Hazardous Substances Data: 127876-62-4(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 127876-59-9 2-(2-(phenylthio)phenyl)ethylamine 

Relevant articles and documents

POTENTIAL ANTIDEPRESSANTS: 2-(PHENYLTHIO)ARALKYLAMINE

Reactions of 2-(phenylthio)benzyl chloride with dimethylamine, diethylamine, pyrrolidine, piperidine, morpholine, and 1-methylpiperazine afforded the title compounds VI-XI.Reaction of 2-(phenylthio)benzaldehyde with nitromethane gave the nitrostyrene XIV which was reduced with lithium aluminium hydride to 2-(2-phenylthio)phenyl)ethylamine (XVI).This was transformed to the N-methyl and N,N-dimethyl derivatives XVIII and XIX.The Claisen reaction of (2-(2-phenylthio)phenyl)acetonitrile with ethyl acetate afforded the compound XXI which was cleaved by phosphoric acid to (2-(phenylthio)phenyl)acetone (XX).The Leuckart-Wallach reaction afforded the formamide XXIII which was used as starting material for preparing the amines XXIV-XXVI.The alternative approach to these compounds starting by reaction of the aldehyde XII with nitroethane was complicated by the fact that in addition to the nitropropene XV 2-(phenylthio)benzonitrile was also formed.The synthetic use of the inhomogenous XV resulted then in mixtures of amines XXIV-XXVI with IV-VI which was followed by means of mass and 1H NMR spectra.The amines XXIV-XXVI were oxidized to the sulfoxides XXVII-XXIX.The oily bases were transformed to crystalline salts and spectra of all homogeneous bases were recorded.Pharmacological testing showed the amine VI (VUFB-15370) to be a promising potential antidepressant.The amines XI and XXV showed also pharmacological profile of potential antidepressant.