127876-63-5

Upstream product

• 127876-64-6 3-oxo-2-(2-(phenylthio)phenyl)butyronitrile 
• 1527-16-8 2-phenylthiophenylacetonitrile 
• 945-51-7 1,1'-sulfinylbisbenzene 
• 144272-12-8 triisopropyl(prop-2-yn-1-yl)silane 

Downstream Products

• 60-15-1 2-amino-1-phenylpropane 
• 127876-71-5 N-methyl-1-(2-(phenylthio)phenyl)-2-propylamine S-oxide 
• 127876-68-0 N-methyl-1-(2-(phenylthio)phenyl)-2-propylamine 
• 127876-70-4 1-(2-(phenylthio)phenyl)-2-propylamine S-oxide 
• 127876-67-9 1-(2-(phenylthio)phenyl)-2-propylamine 
• 127876-66-8 N-(1-(2-(phenylthio)phenyl)-2-propyl)formamide 
• 127876-65-7 (2-(phenylthio)phenyl)acetoxime 

Relevant academic research and scientific papers

Vinyl Cation Stabilization by Silicon Enables a Formal Metal-Free α-Arylation of Alkyl Ketones

The ability of silicon to stabilize vinyl cationic species leads to a redox arylation of alkynes whereby the stringent limitations of reactivity and regioselectivity of alkyl-substituted alkynes are lifted. This allows the synthesis of a range of α-silyl-

POTENTIAL ANTIDEPRESSANTS: 2-(PHENYLTHIO)ARALKYLAMINE

Reactions of 2-(phenylthio)benzyl chloride with dimethylamine, diethylamine, pyrrolidine, piperidine, morpholine, and 1-methylpiperazine afforded the title compounds VI-XI.Reaction of 2-(phenylthio)benzaldehyde with nitromethane gave the nitrostyrene XIV which was reduced with lithium aluminium hydride to 2-(2-phenylthio)phenyl)ethylamine (XVI).This was transformed to the N-methyl and N,N-dimethyl derivatives XVIII and XIX.The Claisen reaction of (2-(2-phenylthio)phenyl)acetonitrile with ethyl acetate afforded the compound XXI which was cleaved by phosphoric acid to (2-(phenylthio)phenyl)acetone (XX).The Leuckart-Wallach reaction afforded the formamide XXIII which was used as starting material for preparing the amines XXIV-XXVI.The alternative approach to these compounds starting by reaction of the aldehyde XII with nitroethane was complicated by the fact that in addition to the nitropropene XV 2-(phenylthio)benzonitrile was also formed.The synthetic use of the inhomogenous XV resulted then in mixtures of amines XXIV-XXVI with IV-VI which was followed by means of mass and 1H NMR spectra.The amines XXIV-XXVI were oxidized to the sulfoxides XXVII-XXIX.The oily bases were transformed to crystalline salts and spectra of all homogeneous bases were recorded.Pharmacological testing showed the amine VI (VUFB-15370) to be a promising potential antidepressant.The amines XI and XXV showed also pharmacological profile of potential antidepressant.