127882-79-5Relevant academic research and scientific papers
Antitumor agents. Part 227: Studies on novel 4′-O-demethyl- epipodophyllotoxins as antitumor agents targeting topoisomerase II
Xiao, Zhiyan,Bastow, Kenneth F.,Vance, John R.,Lee, Kuo-Hsiung
, p. 3339 - 3344 (2007/10/03)
Eight novel epipodophyllotoxin derivatives (6-13), which were designed to overcome drug resistance and enhance topoisomerase II inhibition, were synthesized and evaluated. Two of these compounds (7 and 8) showed better preclinical activity profiles, inclu
Antitumor agents. 113. New 4β-arylamino derivatives of 4'-O-demethylepipodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II
Wang,Kuo,Schnur,Bowen,Liu,Han,Chang,Cheng,Lee
, p. 2660 - 2666 (2007/10/02)
A number of 4'-O-demethylepipodophyllotoxin derivatives possessing various 4β-N-, 4β-O- or 4β-S-aromatic rings have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity in causin
