1279032-06-2Relevant articles and documents
Method for synthesizing substitution N-phenylmorpholine compounds
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Paragraph 0032-0035, (2017/08/30)
The invention discloses a method for synthesizing substitution N-phenylmorpholine compounds. Substituted aniline and 2-chloroethyl ether are heated under the effect of alkali and then are subjected to ring closure to obtain the N-phenylmorpholine compound
GLYCINE COMPOUND
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Page/Page column 24; 78; 87, (2012/07/28)
[Problem] The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases. [Means for Solution] The present inventors have conducted intensive studies on a compound having a VAP-1 inhibitory activity, and as a result, they have found that a compound of the present invention or a salt thereof exhibits an excellent VAP-1 inhibitory activity and is useful for preventing and/or treating VAP-1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention. The present invention further relates to a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases, which comprises the compound of the present invention or a salt thereof, and an excipient.