1279064-25-3Relevant academic research and scientific papers
Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality
Wood, Michael R.,Schirripa, Kathy M.,Kim, June J.,Bednar, Rodney A.,Fay, John F.,Bruno, Joseph G.,Moore, Eric L.,Mosser, Scott D.,Roller, Shane,Salvatore, Christopher A.,Vacca, Joseph P.,Selnick, Harold G.
scheme or table, p. 6827 - 6830 (2011/01/04)
A previously utilized quinoline-for-N-phenylamide replacement strategy was employed against a central amide in a novel class of CGRP receptor antagonists. A unique and unexpected substitution pattern was ultimately required to maintain reasonable affinity
