127911-72-2

Upstream product

• 127840-20-4 Butyric acid 1-(toluene-4-sulfonyloxymethyl)-pentyl ester 
• 1018979-16-2 (+/-)-2-acetoxyhexyl tosylate 

Downstream Products

• 1436-34-6 (R)-1,2-epoxyhexane 
• 1215226-80-4 C₂₀H₂₄O₅S 
• 1215226-79-1 C₂₀H₂₄O₅S 
• 127840-16-8 (R)-2-acetoxyhexyl tosylate 

Relevant academic research and scientific papers

Preparation of optically active 1,2-diol monotosylates by enzymatic hydrolysis

An easy preparation of optically active 1,2-diol monotosylate derivatives by enzymatic hydrolysis is disclosed. Lipase PS (Burkholderia cepacia) catalyzes the hydrolysis of racemic 2-acetoxyhexyl tosylate with excellent enantioselectivity to afford the corresponding optically active compounds. In this reaction, a unique temperature effect is observed. After optimizing the reaction conditions, this procedure is widely applicable to the practical preparation of both enantiomers of various optically active compounds with high ee. Georg Thieme Verlag Stuttgart.

A CHEMOENZYMATIC ACCESS TO OPTICALLY ACTIVE 1,2-EPOXIDES

Lipase-catalyzed transacylation in organic media was employed to produce optically active α-hydroxy tosylate which could be readily converted to the corresponding 1,2-epoxides with high optical purity.