127918-22-3Relevant academic research and scientific papers
Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists
Nagashima, Shinya,Matsushima, Yuji,Hamaguchi, Hisao,Nagata, Hiroshi,Kontani, Toru,Moritomo, Ayako,Koshika, Tadatsura,Takeuchi, Makoto
, p. 3478 - 3487 (2014/06/23)
Herein, we describe the synthesis and pharmacological profiles of novel quinuclidinyl heteroarylcarbamate derivatives. Among them, the quinuclidin-4-yl thiazolylcarbamate derivative ASP9133 was identified as a promising long-acting muscarinic antagonist (LAMA) showing more selective inhibition of bronchoconstriction against salivation and more rapid onset of action in a rat model than tiotropium bromide.
