127925-89-7Relevant academic research and scientific papers
Selective reduction of 2,4-dinitro- and 4,5-dinitroimidazole derivatives using iron dust
Olender, Dorota,Zwawiak, Justyna,Zaprutko, Lucjusz
scheme or table, p. 1049 - 1055 (2010/10/21)
(Chemical Equation Presented) A series of N-substituted 2,4-dinitroimidazoles, 4,5-dinitroimidazoles, and 2-methyl-4,5-dinitroimidazoles have been selectively reduced to the corresponding aminonitroimidazole derivatives, using iron dust in glacial acetic acid at room temperature. 2,4-Dinitroimidazoles have been reduced to the 2-amino-4-nitro-derivatives only but 4,5-dinitroimidazoles have given 4-amino-5-nitro- or 5-amino-4- nitroderivatives depended on the structure of the N-substituent.
Azoles. 27. Nitroimidazole derivatives, their antibacterial and fungicidal activity and electron affinity
Zaprutko,Gajdzinski,Michalska,Pietkiewicz,Lutomski,Lukaszewski,Wrzeciono
, p. 817 - 820 (2007/10/02)
Nitroimidazole derivatives 3a-3g, 4a-4g and 5-8 were synthesized by treating 4,5-dinitro- and 2-methyl-4,5-dinitroimidazole (1,2) with phenacyl bromide, its p-substituted derivatives or epichlorohydrin. 1-(3-Chloro-2-hydroxypropyl)-4,5-dinitroimidazole (5) and its 2-methyl derivative 6 have been converted to imidazo-oxazoles 7 and 8 or amino imidazole derivatives 9-14 by the action of potassium carbonate or cyclic amines (pyrrolidine, piperidine, morpholine and N-methylpiperazine). Some of the newly synthesized nitroimidazole derivatives show antibacterial and fungicidal activity. The electron affinity of the nitroimidazole derivatives 1-24 is discussed on the basis of their half-wave potentials and in the connection with their eventual radiosensitizing properties.
