127927-59-7Relevant academic research and scientific papers
Ring opening of nonactivated 2-(1-aminoalkyl) aziridines: Unusual regio- and stereoselective C-2 and C-3 cleavage
Concellon, Jose M.,Riego, Estela
, p. 6407 - 6410 (2007/10/03)
We have studied the ring opening of nonactivated amino aziridines 1 by water under acidic conditions. Depending on the acid used, amino aziridines are cleaved at C-3 or C-2 with high regioselectivity, and total stereoselectivity, affording chiral 2,3-diam
An improved preparation of epoxides from carbonyl compounds by using diiodomethane/methyllithium: Synthetic applications
Concellón, José M,Cuervo, Humildad,Fernández-Fano, Ramón
, p. 8983 - 8987 (2007/10/03)
Synthesis of epoxides starting from different carbonyl compounds is easily carried out by using a diiodomethane and methyllithium at 0°C and a short reaction time. Starting from α-aminoaldehydes the reaction affords amino epoxides, with high diastereoselectivity. The products were transformed into 1,3-diaminoalkan-2-ols by treatment with different amines.
PROTECTIVE GROUP TUNING IN THE STEREOSELECTIVE CONVERSION OF α-AMINO ALDEHYDES INTO AMINOALKYL EPOXIDES
Reetz, M.T.,Binder, J.
, p. 5425 - 5428 (2007/10/02)
Sulfonium and arsonium ylides of the type CH2=S(CH3)2 and CH2=As(Ph)3 react with doubly protected α-amino aldehydes 1 derived from amino acids to form aminoalkyl epoxides 3/4, diastereofacial selectivity ranging between 86:14 and >95:5.
