127946-07-0Relevant academic research and scientific papers
Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists
Kiesman, William F.,Zhao, Jin,Conlon, Patrick R.,Dowling, James E.,Petter, Russell C.,Lutterodt, Frank,Jin, Xiaowei,Smits, Glenn,Fure, Mary,Jayaraj, Andrew,Kim, John,Sullivan, Gail,Linden, Joel
, p. 7119 - 7131 (2008/04/18)
In the search for a selective adenosine A1 receptor antagonist with greater aqueous solubility than the compounds currently in clinical trials as diuretics, a series of 1,4-substituted 8-cyclohexyl and 8-bicyclo-[2.2.2] octylxanthines were inve
Structure-Activity Relationships of 8-Cycloalkyl-1,3-dipropylxanthines as Antagonists of Adenosine Receptors
Katsushima, T.,Nieves, L.,Wells, J. N.
, p. 1906 - 1910 (2007/10/02)
8-Substituted xanthines currently represent the most potent class of adenosine-receptor antagonists.A series of 8-substituted 1,3-dipropylxanthines was prepared and their potency as antagonists of A1 and A2 adenosine receptors of human platelets and rat a
