127949-75-1Relevant academic research and scientific papers
A CONSISE APPROACH TO FUNCTIONALISED, HOMOCHIRAL PYRROLIDINONES
Bamford, Mark J.,Beard, Mark,Cherry, David T.,Moloney, Mark G.
, p. 337 - 340 (2007/10/02)
Acylation of O,N-acetal 1 gives excellent yields of the C-7 substituted products 2a,b.Alkylation of 2a under mild conditions gives high yields of the exo- 3 and endo- 4 substituted products in varying ratios, depending on the alkylating agent.The unsatura
Amino Acid Synthesis Using (L)-Pyroglutamic Acid as a Chiral Starting Material
Baldwin, Jack E.,Miranda, Tania,Moloney, Mark,Hokelek, Tuncer
, p. 7459 - 7468 (2007/10/02)
Deprotonation of protected pyroglutamates 1(c), 1(d), and 1(e) with lithium di-isopropylamine (LDA) or lithium hexamethyldisilazide (LiHDMS) in THF, followed by reaction with electrophiles, leads to the formation of 4-substituted pyroglutamates in good yield.This approach has been used for the synthesis of the novel amino acid (4).Key Words: pyroglutamic acid; chiral amino acid synthesis
