1279658-95-5Relevant academic research and scientific papers
Concise synthesis of pyrrolidine and indolizidine alkaloids by a highly convergent three-component reaction
Lapointe, Guillaume,Schenk, Kurt,Renaud, Philippe
supporting information; experimental part, p. 3207 - 3212 (2011/04/24)
The synthesis of pyrrolidine and indolizidine derivatives through radical carboazidation of alkenes with α-iodoketones, followed by reductive amination, is described. When properly substituted, further lactamization afforded pyrrolizidinones in good yield. This carboazidation/reductive amination sequence was efficiently applied to the total synthesis of three different simple alkaloids, including (±)-monomorine I.
