1279699-68-1

Basic information

• Product Name: ε-benzyloxycarbonyl-α-dicarboxylmethyl-L-lysine-tris(aminohexyl-β-N-acetylgalactosamine)
• Synonyms: ε-benzyloxycarbonyl-α-dicarboxylmethyl-L-lysine-tris(aminohexyl-β-N-acetylgalactosamine)
• CAS NO: 1279699-68-1
• Molecular Weight: 1303.51
• Mol File: 1279699-68-1.mol

Chemical Properties

• CAS DataBase Reference: ε-benzyloxycarbonyl-α-dicarboxylmethyl-L-lysine-tris(aminohexyl-β-N-acetylgalactosamine)(CAS DataBase Reference)
• NIST Chemistry Reference: ε-benzyloxycarbonyl-α-dicarboxylmethyl-L-lysine-tris(aminohexyl-β-N-acetylgalactosamine)(1279699-68-1)
• EPA Substance Registry System: ε-benzyloxycarbonyl-α-dicarboxylmethyl-L-lysine-tris(aminohexyl-β-N-acetylgalactosamine)(1279699-68-1)

Safety Data

• Hazardous Substances Data: 1279699-68-1(Hazardous Substances Data)

Upstream product

• 209052-01-7 2,2'-((5-(((benzyloxy)carbonyl)amino)-1-carboxypentyl)azanediyl)diacetic acid 
• 110101-40-1 6-aminohexyl 2-acetamido-2-deoxy-β-D-galactopyranoside 
• 113231-04-2 N_α,N_α-bis(carboxymethyl)-N_ε-(benzyloxycarbonyl)-L-lysine 

Relevant articles and documents

NOVEL LIVER-TARGETING AGENTS AND THEIR SYNTHESIS

This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilo triacetic acid structure as backbone which acquires multivalency with saccharide groups, to bind with a galactosamine chain or lactose chain is disclosed. In particular, only one amino acid L-lysine is involved to provide trivalency. All carboxyl groups in Nε-benzyloxycarbonyl-Nα-dicarboxymethyl-L-lysine can be conjugated with three glycosides of ahGalNAc or ahLac in one step. This invention also provides a hexa-lactoside. In particular, the TFA-AHA-Asp was used to conjugate 2 moles of NTA(ahLac)3. This invention also provides a method for adding a spacer between NTA and DTPA. The extended hepatocyte-specific glyco-ligand has higher 111In-radiolabelling yield than those non-extended.

New and more efficient multivalent glyco-ligands for asialoglycoprotein receptor of mammalian hepatocytes

New multi-valent, carbohydrate ligands that contain terminal N-acetylgalactosamine (GalNAc) or lactose (Lac) were prepared using a nitrilotriacetic acid (NTA) derivative of l-lysine as scaffold. Tri-valent structures were prepared by attaching an ω-amino