127974-71-4

Basic information

• Product Name: (+)-(2S,3S,4R)-2-(Benzyloxy)-3-<<3-methoxy-4,5-(methylenedioxy)phenyl>bis(phenylthio)methyl>-4-<3,4-(methylenedioxy)benzoyl>tetrahydrofuran
• CAS NO: 127974-71-4
• Molecular Weight: 706.837
• Mol File: 127974-71-4.mol

Chemical Properties

• CAS DataBase Reference: (+)-(2S,3S,4R)-2-(Benzyloxy)-3-<<3-methoxy-4,5-(methylenedioxy)phenyl>bis(phenylthio)methyl>-4-<3,4-(methylenedioxy)benzoyl>tetrahydrofuran(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(2S,3S,4R)-2-(Benzyloxy)-3-<<3-methoxy-4,5-(methylenedioxy)phenyl>bis(phenylthio)methyl>-4-<3,4-(methylenedioxy)benzoyl>tetrahydrofuran(127974-71-4)
• EPA Substance Registry System: (+)-(2S,3S,4R)-2-(Benzyloxy)-3-<<3-methoxy-4,5-(methylenedioxy)phenyl>bis(phenylthio)methyl>-4-<3,4-(methylenedioxy)benzoyl>tetrahydrofuran(127974-71-4)

Safety Data

• Hazardous Substances Data: 127974-71-4(Hazardous Substances Data)

Upstream product

• 882-33-7 diphenyldisulfane 
• 5780-07-4 3-methoxy-4,5-methylenedioxybenzaldehyde 
• 120040-58-6 Benzo[1,3]dioxol-5-yl-((R)-5-benzyloxy-2,5-dihydro-furan-3-yl)-methanol 
• 104322-41-0 (+)-(2R)-benzyloxy-2,5-dihydrofuran-4-carboxaldehyde 
• 2635-13-4 1,2-(methylenedioxy)-4-bromobenzene 
• 127974-64-5 5--1-methoxy-2,3-(methylenedioxy)benzene 
• 120040-59-7 (-)-(2R)-2-(Benzyloxy)-2,5-dihydro-4-<3,4-(methylenedioxy)benzoyl>furan 

Relevant articles and documents

General Conjugate-Addition Method for the Synthesis of Enantiomerically Pure Lignans. Total Synthesis of (-)- and (+)-Burseran, (-)-Dehydroxycubebin, (-)-Trichostin, (-)-Cubebin, (-)-5''-Methoxyhinokinin, and (-)-Hinokinin

Conjugate addition of benzylic diphenyldithioacetal anions to enantiomerically pure (-)-(2R)-and (+)-(2S)-(benzyloxy)-2,5-dihydro-4-furan (2 r and 2 s) gave complete lignan skeletons of the dibenzylbutane class.Desulfurization followed by hydrogenolysis and, when appropriate, oxidation gave the title enantiomerically pure > 99 percent ee) lignans 45 - 50 in 24 - 35 percent overall yields from 2 r and 2 s.