1279817-20-7Relevant academic research and scientific papers
Regioselective addition of Grignard reagents to N-acylpyrazinium salts: Synthesis of substituted 1,2-dihydropyrazines and Δ5-2-oxopiperazines
St Hilaire, Valentine R.,Hopkins, William E.,Miller, Yenteeo S.,Dandepally, Srinivasa R.,Williams, Alfred L.
supporting information, p. 72 - 78 (2019/01/28)
The regioselective addition of Grignard reagents to mono- and disubstituted N-acylpyrazinium salts affording substituted 1,2-dihy-dropyrazines in modest to excellent yields (45–100%) is described. Under acidic conditions, these 1,2-dihydropyrazines can be converted to substituted Δ5-2-oxopiperazines providing a simple and efficient approach towards their preparation.
Synthesis of mono- and diaza-'pyridones' via stille coupling of alkoxystannanes
Smith, Charlotte L.,Hirschh?user, Christoph,Malcolm, Georgia K.,Nasrallah, Daniel J.,Gallagher, Timothy
, p. 1904 - 1908 (2014/08/18)
Various alkoxy-substituted heterocyclic stannanes provide access to the corresponding substituted 'pyridone' moieties via Stille cross-coupling. Both pyridyl and a series of diazinyl stannanes are prepared, and options for unmasking (via demethylation or debenzylation) of the pyridone unit are evaluated. Georg Thieme Verlag Stuttgart. New York.
