127985-74-4Relevant articles and documents
Prevention of systemic toxicity during radioimmunotherapy for intravascularly disseminated cancers
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, (2008/06/13)
The present invention provides a method to target delivery of antibody constructs radiolabeled with an alpha-particle emitting radionuclide to intravascularly disseminated tumor cells while minimizing systemic toxicity. Targeted delivery of a construct specific for a protein expressed on the tumor cells in combination with rapid clearance of intravascular non-targeted radiolabeled antibody construct minimizes alpha particle emissions from the radionuclide and its alpha-particle emitting decay intermediates to non-targeted cells.