127986-88-3

Basic information

• Product Name: ((S)-1-Benzyl-pyrrolidin-2-yl)-di-naphthalen-2-yl-methanol
• Synonyms: ((S)-1-Benzyl-pyrrolidin-2-yl)-di-naphthalen-2-yl-methanol
• CAS NO: 127986-88-3
• Molecular Weight: 443.588
• Mol File: 127986-88-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((S)-1-Benzyl-pyrrolidin-2-yl)-di-naphthalen-2-yl-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-1-Benzyl-pyrrolidin-2-yl)-di-naphthalen-2-yl-methanol(127986-88-3)
• EPA Substance Registry System: ((S)-1-Benzyl-pyrrolidin-2-yl)-di-naphthalen-2-yl-methanol(127986-88-3)

Safety Data

• Hazardous Substances Data: 127986-88-3(Hazardous Substances Data)

Upstream product

• 21473-01-8 2-naphthalenylmagnesium bromide 
• 113304-84-0 N-benzyl-(S)-proline methyl ester 

Downstream Products

• 130798-48-0 (S)-(-)-α,α-di(2-naphthyl)-2-pyrrolidinemethanol 

Relevant articles and documents

A NEW CHIRAL CATALYST FOR THE ENANTIOSELECTIVE SYNTHESIS OF SECONDARY ALCOHOLS AND DEUTERATED PRIMARY ALCOHOLS BY CARBONYL REDUCTION

An efficient synthesis of (S)-(-)-2-(di-β-naphthylhydroxymethyl)pyrrolidine (1) makes available the oxazaborolidine derivates 2 and 3 which are excellent catalysts for borane reduction of a variety of achiral ketones to chiral secondary alcohols, e.g. acetophenone, 98percent ee; α-tetralone, 95percent ee; and methyl-4-oxo-4-phenyl butyrate, 96percent ee.The synthesis of chiral 1-deuterio primary alcohols from achiral aldehydes with B-n-butyloxazaborolidine (4) as catalyst in the presence of 2H-catecholborane as reductant has also been demonstrated, e.g. benzaldehyde, 95percent ee; cyclohexanecarboxaldehyde, 92percent ee; and n-octanal, 90percent ee.